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One-pot synthesis of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines and their reactions

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Chemistry of Heterocyclic Compounds Aims and scope

A series of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines was obtained as a result of a multicomponent Biginelli reaction using 1,3-dicarbonyl compounds, aromatic aldehydes, and cyanamide. Alkylation of the obtained compounds with benzyl chloride takes place at the two nitrogen atoms of the tetrahydropyrimidine ring, while oxidation with manganese dioxide leads to the corresponding 1-(pyrimidin-2-yl)carbamides or pyrimidine-2-amines, depending on the conditions.

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Authors and Affiliations

  1. Voronezh State University, 1 Universitetskaya Sq., Voronezh, 394006, Russia

    A. H. Moustafa, A. S. Shestakov & Kh. S. Shikhaliev

Authors
  1. A. H. Moustafa
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  2. A. S. Shestakov
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  3. Kh. S. Shikhaliev
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Correspondence to A. H. Moustafa.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 658-664, April, 2012.

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Moustafa, A.H., Shestakov, A.S. & Shikhaliev, K.S. One-pot synthesis of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines and their reactions. Chem Heterocycl Comp 48, 613–619 (2012). https://doi.org/10.1007/s10593-012-1034-y

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  • DOI: https://doi.org/10.1007/s10593-012-1034-y

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