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Synthesis of 6-sulfamoylsaccharin and study of its reactivity in alkylation reactions

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Chemistry of Heterocyclic Compounds Aims and scope

An improved method for the preparation of 6-sulfamoylsaccharin (3-oxo-2,3-dihydro-1,2-benzo-thiazole-6-sulfonamide 1,1-dioxide) has been developed and studies of its possible direct alkylation have been carried out. It was shown that alkylation occurs regioselectively at the isothiazoline ring nitrogen atom.

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This work was carried out with the financial support of the European Social Fund (No. 2009/0203/1DP/1.1.1.2.0/APIA/VIAA/023).

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia

    E. M. Ivanova, E. Yu. Simin, I. V. Vozny, P. Trapencieris & R. Žalubovskis

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  1. E. M. Ivanova
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  2. E. Yu. Simin
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  3. I. V. Vozny
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  4. P. Trapencieris
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  5. R. Žalubovskis
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Correspondence to R. Žalubovskis.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1865-1868, December, 2011.

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Ivanova, E.M., Simin, E.Y., Vozny, I.V. et al. Synthesis of 6-sulfamoylsaccharin and study of its reactivity in alkylation reactions. Chem Heterocycl Comp 47, 1561–1564 (2012). https://doi.org/10.1007/s10593-012-0948-8

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  • DOI: https://doi.org/10.1007/s10593-012-0948-8

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