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Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

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Abstract

Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Interstitial cells of Cajal (ICC) are apparently pacemaker cells, and their loss could cause motor dysfunction. In this study, we developed a mouse model for GCPM, and investigated electrophysiological changes in the small intestine and attendant changes in ICC. We found decreased ICC and disrupted electrical rhythm in the model. Pathologic ICC changes were well described. Cancer peritoneal metastasis may impair intestinal myoelectrical activity by damaging ICC and ICC networks. Interstitial cells of Cajal will be a target of palliative treatment and merit further study.

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Abbreviations

GCPM:

Gastric cancer peritoneal metastasis

ICC:

Interstitial cells of Cajal

ICC-DMP:

ICC in the deep muscular plexus

ICC-IM:

ICC within the circular and longitudinal layers of muscle

ICC-MY:

ICC in the myenteric plexus

ICC-SMP:

ICC in the submuscular plexus

IgG:

Immunoglobulin G

NOS:

Nitric oxide synthase

RT-PCR:

Reverse transcriptase-polymerase chain reaction

SCF:

Stem cell factor

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Acknowledgments

This work was supported by grant of Harbin Science and Technology Bureau.(2007AA3CS083) and grant of Science and Technology Department of Heilongjiang Province.(GC07C35101).

The research depends on the cooperation of the two different departments. So we consider that Hongqun Zheng and Yan He contributed equally to this work. Qifan Zhang and Xiaoming Jin are both as Correspondence.

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Authors and Affiliations

  1. Department of Oncology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, China

    Hongqun Zheng, Jinxue Tong, Lingyu Sun, Dongdong Yang & Qifan Zhang

  2. Department of Pathology, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, China

    Yan He, Huaming Li, Ning Ao & Xiaoming Jin

Authors
  1. Hongqun Zheng
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  2. Yan He
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  3. Jinxue Tong
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  4. Lingyu Sun
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  5. Dongdong Yang
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  6. Huaming Li
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  7. Ning Ao
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  8. Xiaoming Jin
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  9. Qifan Zhang
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Corresponding authors

Correspondence to Xiaoming Jin or Qifan Zhang.

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Zheng, H., He, Y., Tong, J. et al. Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?. Clin Exp Metastasis 28, 291–299 (2011). https://doi.org/10.1007/s10585-010-9371-7

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  • DOI: https://doi.org/10.1007/s10585-010-9371-7

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