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The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System

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Abstract

The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain function, as the abnormal regulation of GluN2A may induce some neuropsychiatric disorders. This review will examine the regulation of GluN2A by endogenous and exogenous regulators in the central nervous system.

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Acknowledgments

The authors acknowledge support from the Natural Science Foundation of China (NSFC 81200886, NSFC 81402886), the Natural Science Foundation of Hebei Province (H2014208004), the Science and Technology Project of Hebei Province (13397703D), the Key Basic Research Program of the Application Foundation Research Project of Hebei Province (14967719D, 15962704D), the State Key Laboratory Breeding Base—Hebei Key Laboratory of Molecular Chemistry for Drug and Hebei Research Center of Pharmaceutical and Chemical Engineering.

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  1. Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, People’s Republic of China

    Yongjun Sun, Liying Zhan & Zibin Gao

  2. Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, People’s Republic of China

    Yongjun Sun & Zibin Gao

  3. North China Pharmaceutical Group New Drug Research and Development Co., Ltd, Shijiazhuang, 050015, People’s Republic of China

    Xiaokun Cheng

  4. Department of Pathophysiology, Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China

    Linan Zhang

  5. School of Nursing, Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China

    Jie Hu

  6. State Key Laboratory Breeding Base—Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, 050018, People’s Republic of China

    Zibin Gao

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  1. Yongjun Sun
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  4. Linan Zhang
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Correspondence to Zibin Gao.

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Sun, Y., Zhan, L., Cheng, X. et al. The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System. Cell Mol Neurobiol 37, 389–403 (2017). https://doi.org/10.1007/s10571-016-0388-6

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