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Construction of cellulose/nanosilver sponge materials and their antibacterial activities for infected wounds healing

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Abstract

Antibacterial sponges with the silver nanoparticles (Ag NPs) were constructed by freeze-drying of cellulose composite hydrogels, which were prepared in NaOH/urea aqueous system with cooling, where the interconnecting pores of the sponge not only were used as micro-reactors to synthesize Ag nanoparticles but also inhibited the aggregation of Ag NPs. The Ag nanoparticles with size range from 4 to 50 nm, depending on the AgNO3 concentration, were uniformly immobilized in the cellulose/nanosilver sponges. The cellulose/nanosilver composite materials exhibited excellent antibacterial activities. Further, in vivo tests confirmed that the composite sponges had an ability to accelerate infected wound healing, as a result of the existence of the antibacterial Ag nanoparticles and absorbing capacity for wound exudate. The experimental data strongly encouraged the use of cellulose/nanosilver composite sponge as antibacterial materials, especially in case of serious wound infection. The composite cellulose sponge containing Ag nanoparticles provided an alternative material for the application of the infected wound healing.

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Acknowledgments

This work was supported by the National Basic Research Program of China (973 Program, 2010CB732203), the Major Program of Natural Science Foundation of China (21334005), and the National Natural Science Foundation of China (20874079 and 21304021).

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Authors and Affiliations

  1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China

    Dongdong Ye, Hui Xu, Chunyu Chang & Lina Zhang

  2. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan, 430071, China

    Zibiao Zhong, Zixuan Yang, Yanfeng Wang & Qifa Ye

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  1. Dongdong Ye
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  2. Zibiao Zhong
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  3. Hui Xu
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  4. Chunyu Chang
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  8. Lina Zhang
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Correspondence to Chunyu Chang or Lina Zhang.

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Ye, D., Zhong, Z., Xu, H. et al. Construction of cellulose/nanosilver sponge materials and their antibacterial activities for infected wounds healing. Cellulose 23, 749–763 (2016). https://doi.org/10.1007/s10570-015-0851-4

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