Abstract
Nano-scaled particles were obtained from two different cellulose acetates, cellulose acetate propionate, and cellulose acetate butyrate using the emulsification solvent evaporation procedure and the low energy methods of solvent displacement (dialysis and controlled precipitation). The relationship between the formulation parameters and the particle properties were evaluated in case of the emulsification-evaporation technique. For the solvent displacement procedures, the influence of the formulation parameters, and the intrinsic polymer properties like the hydrophilic-hydrophobic balance was evaluated. Comparing the methods, it could be shown that large amounts of small and uniform nanoparticles can be obtained by the emulsification solvent evaporation procedure. The solvent displacement techniques turned out to be very easy to use and to yield narrowly distributed particles as well.
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Acknowledgments
Finnish Funding Agency for Technology and Innovation (Tekes), Thuringian Ministry for Education, Science and Culture (grant #B514-09051, NanoConSens) and the Thuringian development bank (grant #2008 FE 9183] are acknowledged for funding. The authors thank Manuela Kötteritzsch, Peggy Laudeley, Katrin Otto and Franziska Busch for their technical assistance.
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Member of the European Polysaccharide Network of Excellence (EPNOE), http://www.epnoe.eu.
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Wondraczek, H., Petzold-Welcke, K., Fardim, P. et al. Nanoparticles from conventional cellulose esters: evaluation of preparation methods. Cellulose 20, 751–760 (2013). https://doi.org/10.1007/s10570-013-9874-x
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DOI: https://doi.org/10.1007/s10570-013-9874-x