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Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology

  • Epidemiology
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Abstract

The aim of the study is to verify the hypothesis that genetic polymorphisms are associated with the predisposition to all malignancies. Using as a model breast cancers from the homogenous Polish population (West Pomeranian region) after stratification of 977 patients by age at diagnosis (under 51 years and above 50 years) and by tumour pathology (ductal cancers––low and high grade, lobular cancers, ER-positive/negative) we tested this hypothesis. Altogether 20 different groups of breast cancer cases have been analyzed. The results were compared to a group of unaffected controls that were matched by age, sex, ethnicity and geographical location and originated from families without cancers of any site among relatives. Molecular alterations selected for analyses included those which have been previously recognized as being associated with breast cancer predisposition. Statistically significant differences between the breast cancer cases and controls were observed in 19 of the 20 analyzed groups. Genetic changes were present in more than 90% of the breast cancer patients in 18 of 20 groups. The highest proportion of cases with constitutional changes—99.3% (139/140) was observed for lobular cancers. The number and type of genetic marker and/or the level of their association with the specific cancer predisposition was different between groups. Markers associated with majority of groups included: BRCA1, CHEK2, p53, TNRnTT, FGFRnAA, XPD CC/AA and XPD GG. Some markers appeared to be group specific and included polymorphisms in CDKN2A, CYP1B1, M3K nAA, and RS67.

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Acknowledgment

Authors thank Ms. E. Putresza for excellent technical support. Publication supported by grant of Polish Ministry of Science, No PBZ-KBN-122/PO5/2004.

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Authors and Affiliations

  1. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Polabska 4, 70-115, Szczecin, Poland

    Jan Lubiński, Bohdan Górski, Cezary Cybulski, Tadeusz Dębniak, Anna Jakubowska, Katarzyna Jaworska, Dominika Wokołorczyk, Krzysztof Mędrek, Joanna Matyjasik, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Bartłomiej Masojć, Marcin Lener, Anna Szymańska, Jolanta Szymańska-Pasternak & Pablo Serrano-Fernàndez

  2. Faculty of Computer Science and Information Systems, Technical University of Szczecin, Żołnierska 49, 71-210, Szczecin, Poland

    Marcin Korzeń & Andrzej Piegat

  3. Regional Oncology Hospital, Strzałowska 22, 71-730, Szczecin, Poland

    Rafał Uciński

  4. Department of Pathology, Pomeranian Medical University, Unii Lubelskiej 1, 71-242, Szczecin, Poland

    Paweł Domagała, Wenancjusz Domagała & Maria Chosia

  5. Department of General and Vascular Surgery, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-211, Szczecin, Poland

    Józef Kładny

  6. Department of Radiology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-211, Szczecin, Poland

    Barbara Górecka

  7. Centre for Research on Women’s Health, University of Toronto, Toronto, ON, Canada

    Steven Narod

  8. Discipline of Medical Genetic, Faculty of Health, The Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia

    Rodney Scott

Authors
  1. Jan Lubiński
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  2. Marcin Korzeń
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  3. Bohdan Górski
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  4. Cezary Cybulski
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  5. Tadeusz Dębniak
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  6. Anna Jakubowska
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  7. Katarzyna Jaworska
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  8. Dominika Wokołorczyk
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  9. Krzysztof Mędrek
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  10. Joanna Matyjasik
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  11. Tomasz Huzarski
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  12. Tomasz Byrski
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  13. Jacek Gronwald
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  14. Bartłomiej Masojć
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  15. Marcin Lener
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  16. Anna Szymańska
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  17. Jolanta Szymańska-Pasternak
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  18. Pablo Serrano-Fernàndez
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  19. Andrzej Piegat
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  20. Rafał Uciński
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  21. Paweł Domagała
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  22. Wenancjusz Domagała
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  23. Maria Chosia
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  24. Józef Kładny
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  25. Barbara Górecka
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  26. Steven Narod
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  27. Rodney Scott
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Correspondence to Jan Lubiński.

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Lubiński, J., Korzeń, M., Górski, B. et al. Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology. Breast Cancer Res Treat 114, 121–126 (2009). https://doi.org/10.1007/s10549-008-9974-8

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  • DOI: https://doi.org/10.1007/s10549-008-9974-8

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