Abstract
The NOD2 gene has been associated with susceptibility to Crohn’s disease, and more recently with carcinoma of the colon as well. NOD2 is involved in the inflammatory response and the activation of the NFkB pathway. The range of cancer types associated with NOD2 has not been well studied. The 3020insC allele results in a truncated NOD2 protein and is present in approximately 7% of the population. We studied a possible association between the 3020insC allele of the NOD2 gene and breast cancer using 462 cases and 1910 controls from Poland. Patients were diagnosed with invasive breast cancer at are of two Szczecin regional hospitals between 2002 and 2004. Pathology specimens were reviewed for histological subtype and for the presence of ductal carcinoma in situ (DCIS). Overall there was no association between breast cancer and NOD2 (OR=1.1; p=0.76), but significant associations were observed between the presence of the allele and early-onset breast cancer (OR=1.9; p=0.01) and between the allele and ductal breast cancer with an in situ component (OR=2.2; p=0.006).
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References
Guiterrez et al. (2002) ArticleTitleInduction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kB J Biol Chem 277 41701–41705
Y Ogura N Inohara A Benito FF Chen S Yamaoka G Nunez (2001) ArticleTitleNod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB J Biol Chem 276 4812–4818
Y Ogura DK Bonen N Inohara DL Nicolae FF Chen R Ramos H Britton T Moran R Karaliuskas RH Duerr JP Achkar SR Brant TM Bayless BS Kirschner SB Hanauer G Nunez JH Cho (2001) ArticleTitleA frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease Nature 411 603–606 Occurrence Handle10.1038/35079114 Occurrence Handle1:CAS:528:DC%2BD3MXksVShur8%3D Occurrence Handle11385577
J Hampe A Cuthbert PJ Croucher MM Mirza S Mascheretti S Fisher H Frenzel K King A Hasselmeyer AJ MacPherson S Bridger S van Deventer A Forbes S Nikolaus JE Lennard-Jones UR Foelsch M Krawczak C Lewis S Schreiber CG Mathew (2001) ArticleTitleAssociation between insertion mutation in NOD2 gene and Crohn’s disease in German and British populations Lancet 357 1925–1928 Occurrence Handle10.1016/S0140-6736(00)05063-7 Occurrence Handle1:CAS:528:DC%2BD3MXks1OisLk%3D Occurrence Handle11425413
G Kurzawski J Suchy J Kladny E Grabowska M Mierzejewski A Jakubowska T Debniak et al. (2004) ArticleTitleThe Nod2 3020insC mutation and the risk of colorectal cancer Cancer Res 64 1604–1606
InstitutionalAuthorNameCHEK2 Breast Cancer Case-Control consortium (2004) ArticleTitleCHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9065 controls from 10 studies Am J Hum Genet 74 1175–1182
B Gorski T Byrski T Huzarski et al. (2001) ArticleTitleFounder mutations in the BRCA1 gene in Polish families with breast-ovarian cancer Am J Hum Genet 66 1963–1968
Kurzawski G, Suchy J, Kladny J et al.: Germline MSH2 and␣MLH1 mutational spectrum in HNPCC families from Poland␣and the Baltic States. J Med Genet 39: E65, 2002
Tavassoli FA, Devilee P: WHO Classification of Tumours–Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press, Lyon, 2003, pp 67–73.
EB Claus M Stowe D Carter (2003) ArticleTitleFamily history of breast and ovarian cancer and the risk of breast carcinoma in situ Breast Cancer Res Treatment 78 7–15
EB Claus M Stowe D Carter T Holford (2003) ArticleTitleThe risk of contralateral breast cancer among women diagnosed for the ductal and lobular breast carcinoma in situ: from the Connecticut Tumour Registry Breast 12 451–456
CC Sun G Lenoir S.A Lynch Narod (1996) ArticleTitleIn situ breast cancer and BRCA1 Lancet 348 408
SR Lakhani MJ Van de Vijver J Jacquemier TJ Anderson PP Osin L McGuffog DF Easton (2002) ArticleTitleThe pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2 J Clin Oncol 20 2310–2318
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Huzarski, T., Lener, M., Domagała, W. et al. The 3020insC allele of NOD2 predisposes to early-onset breast cancer. Breast Cancer Res Treat 89, 91–93 (2005). https://doi.org/10.1007/s10549-004-1250-y
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DOI: https://doi.org/10.1007/s10549-004-1250-y