Abstract
This study investigates the mechanical and long-term electrical properties of parylene-caulked polydimethylsiloxane (PDMS) as a substrate for implantable electrodes. The parylene-caulked PDMS is a structure where particles of parylene fill the porous surface of PDMS. This material is expected to have low water absorption and desirable mechanical properties such as flexibility and elasticity that are beneficial in many biomedical applications. To evaluate the mechanical property and electrical stability of parylene-caulked PDMS for potential in-vivo uses, tensile tests were conducted firstly, which results showed that the mechanical strength of parylene-caulked PDMS was comparable to that of native PDMS. Next, surface electrodes based on parylene-caulked PDMS were fabricated and their impedance was measured in phosphate-buffered saline (PBS) solution at 36.5 °C over seven months. The electrodes based on parylene-caulked PDMS exhibited the improved stability in impedance over time than native PDMS. Thus, with improved electrical stability in wet environment and preserved mechanical properties of PDMS, the electrodes based on parylene-caulked PDMS are expected to be suitable for long-term in-vivo applications.
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References
ASTM D412-06a, Standard test methods for vulcaizaed rubber and thermoplastic elastomers-tension, www.astm.org (2012).
M. J. Baker, J. Trevisan, P. Bassan, R. Bhargava, H. J. Butler, K. M. Dorling, P. R. Fielden, S. W. Fogarty, N. J. Fullwood, K. A. Heys, C. Hughes, P. Lasch, P. L. Martin-Hirsch, B. Obinaju, G. D. Sockalingum, J. Sulé-Suso, R. J. Strong, M. J. Walsh, B. R. Wood, P. Gardner, F. L. Martin, Nat Protoc 9, 1771 (2014)
D. Byun, S. J. Cho, S. Kim, J Micromech Microeng 23, 125010 (2013)
E. Castagnola, A. Ansaldo, E. Maggiolini, T. Ius, M. Skrap, D. Ricci, L. Fadiga, Front Neuroeng 7, 8 (2014)
V. Castagnola, E. Descamps, A. Lecestre, L. Dahan, J. Remaud, L. G. Nowak, C. Bergaud, Biosens Bioelectron 67, 450 (2015)
K. C. Cheung, Biomed Microdevices 9, 923 (2007)
K. M. Choi, J. A. Rogers, J Am Chem Soc 125, 4060 (2003)
N. Chou, J. Jeong, S. Kim, J Micromech Microeng 23, 125035 (2013a)
N. Chou, S. Yoo, S. Kim, IEEE Trans Neural Syst Rehabil Eng 21, 544 (2013b)
W. Chun, N. Chou, S. Cho, S. Yang, S. Kim, Prog Org Coat 77, 537 (2014)
E. M. Davis, N. M. Benetatos, W. F. Regnault, K. I. Winey, Y. A. Elabd, Polymer 52, 5378 (2011)
O. Graudejus, P. Görrn, S. Wagner, ACS Appl Mater Interfaces 2, 1927 (2010)
P. Grosse, Clin Neurophysiol 113, 1523 (2002)
L. Guo, G. S. Guvanasen, X. Liu, C. Tuthill, T. R. Nichols, S. P. DeWeerth, IEEE Trans Biomed Circuits Syst 7, 1 (2013)
R. R. Harrison, IEEE Cust Integr Circuits Conf (IEEE, 2007), 115–122 (2007)
J. M. Hsu, L. Rieth, R. A. Normann, P. Tathireddy, F. Solzbacher, IEEE Trans Biomed Eng 56, 23 (2009)
J. Jean, A. Wang, V. Bulović, Org Electron 31, 120 (2016)
J. Jeong, N. Chou, and S. Kim. Int IEEE/EMBS Conf Neural Eng NER 911 (2013).
X. Kang, J.-Q. Liu, H. Tian, B. Yang, Y. Nuli, C. Yang, J Microelectromech Syst 24, 319 (2015)
X. Kang, J. Liu, H. Tian, B. Yang, Y. NuLi, C. Yang, Sensors Actuators B Chem 225, 267 (2016)
S. J. Kim, I. T. Lee, H.-Y. Lee, Y. H. Kim, Smart Mater Struct 15, 1540 (2006)
B. J. Kim, C. A. Gutierrez, E. Meng, J Microelectromech Syst 24, 1534 (2015)
J. T. W. Kuo, B. J. Kim, S. A. Hara, C. D. Lee, C. A. Gutierrez, T. Q. Hoang, E. Meng, Lab Chip 13, 554 (2013)
K. Lee, A. Singh, J. He, S. Massia, B. Kim, G. Raupp, Sensors Actuators B Chem 102, 67 (2004)
Y. Lei, Y. Liu, W. Wang, W. Wu, Z. Li, Lab Chip 11, 1385 (2011)
M. Ludvigsson, J. Lindgren, J. Tegenfeldt, Electrochim Acta 45, 2267 (2000)
A. Mercanzini, K. Cheung, D. L. Buhl, M. Boers, A. Maillard, P. Colin, J. C. Bensadoun, A. Bertsch, P. Renaud, Sensors actuators. A Phys 143, 90 (2008)
R. A. Normann, Nat Clin Pract Neurol 3, 444 (2007)
M. Ochoa, P. Wei, A. J. Wolley, K. J. Otto, B. Ziaie, Biomed Microdevices 15, 437 (2013)
D. C. Rodger, A. J. Fong, W. Li, H. Ameri, A. K. Ahuja, C. Gutierrez, I. Lavrov, H. Zhong, P. R. Menon, E. Meng, J. W. Burdick, R. R. Roy, V. R. Edgerton, J. D. Weiland, M. S. Humayun, Y. C. Tai, Sensors actuators. B Chem 132, 449 (2008)
F. J. Rodri’guez, D. Ceballos, M. Schu¨ttler, A. Valero, E. Valderrama, T. Stieglitz, X. Navarro, J Neurosci Methods 98, 105 (2000)
P. J. Rousche, D. S. Pellinen, D. P. Pivin, J. C. Williams, R. J. Vetter, D. R. Kipke, IEEE Trans Biomed Eng 48, 361 (2001)
B. Rubehn, T. Stieglitz, Biomaterials 31, 3449 (2010)
Y. Rui, J. Liu, Y. Wang, C. Yang, Microsyst Technol 17, 437 (2011)
J. P. Seymour, Y. M. Elkasabi, H. Y. Chen, J. Lahann, D. R. Kipke, Biomaterials 30, 6158 (2009)
T. Stieglitz, M. Schuettler, K. P. Koch, IEEE Eng Med Biol Mag 24, 58 (2005)
M. W. Toepke, D. J. Beebe, Lab Chip 6, 1484 (2006)
A. V. Vasenkov, J Mol Model 17, 3219 (2011)
R. P. Von Metzen, T. Stieglitz, Biomed Microdevices 15, 727 (2013)
S. Yamagiwa, M. Ishida, T. Kawano, Appl Phys Lett 107, 083502 (2015)
Acknowledgments
This research was supported by grants from the Basic Science Research Program of the National Research Foundation (2014R1A1A3050285), the Integrative Aging Research Center of the Gwangju Institute of Science and Technology (GIST), DGIST MIREBraiN Program (2016010043) and R&D Program (16-BD-0404) funded by the Ministry of Science, ICT and Future Planning, Korea.
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Jeong, J., Chou, N. & Kim, S. Long-term characterization of neural electrodes based on parylene-caulked polydimethylsiloxane substrate. Biomed Microdevices 18, 42 (2016). https://doi.org/10.1007/s10544-016-0065-z
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DOI: https://doi.org/10.1007/s10544-016-0065-z