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Sugar Micro Needles as Transdermic Drug Delivery System

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Abstract

We designed and fabricated an array of sugar micro needles of the length ranging from 150 μ m to 2 mm for transdermic delivery of drugs. Micro needles were molded out of maltose mixed with pharmaceutical material, being expected bio-degradable in the human skin. To test basic tolerance to the healthy human skin, a clinical experiment was carried out for 10 healthy adult volunteers. 500 μ m-needles containing 5 wt% of ascorbate-2-glycoside were inserted into the skin of the forearm and snapped off to be left in the skin. They spontaneously dissolved by hydrolysis to release ascorbate in the epidermis and the dermis. No dermatological problems were observed in terms of the International Contact Dermatitis Research Group criteria. These observations indicate that the present system is a novel approach to achieve transdermic drug delivery.

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Authors and Affiliations

  1. Department of Micro System Technology, Ritsumeikan University, Noji-Higashi 1-1-1, Kusatsu, Shiga, 525-8577, Japan

    Takaya Miyano & Katsumi Hanada

  2. Nano Device and System Research Incorporation, Higashi-Shiokoji-cho, 608-9, Shimogyo-ku, Kyoto, 600-8216, Japan

    Yoshikazu Tobinaga

  3. Department of Physiology, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, Aomori, 036-8562, Japan

    Takahiro Kanno & Makoto Wakui

  4. Department of Dermatology, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, Aomori, 036-8562, Japan

    Yasushi Matsuzaki & Hitoshi Takeda

Authors
  1. Takaya Miyano
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  2. Yoshikazu Tobinaga
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  3. Takahiro Kanno
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  4. Yasushi Matsuzaki
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  5. Hitoshi Takeda
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  6. Makoto Wakui
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  7. Katsumi Hanada
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Corresponding author

Correspondence to Takaya Miyano.

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Miyano, T., Tobinaga, Y., Kanno, T. et al. Sugar Micro Needles as Transdermic Drug Delivery System. Biomed Microdevices 7, 185–188 (2005). https://doi.org/10.1007/s10544-005-3024-7

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  • DOI: https://doi.org/10.1007/s10544-005-3024-7

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