Abstract
Digital microneedling and drug delivery dermal or subcutaneous injection of active ingredients, especially when associated with procedures based on microneedling, are able to stimulate the tissue by the action of both the puncture and the drugs. Recently, transdermal drug delivery systems with microneedles have been developed for the infusion of lipophilic, hydrophilic, and macromolecule active ingredients directly at their site of action. Its main characteristics are the possibility of using ingredients of different densities and in many anatomical sites, from the epidermis to the hypodermis, with total control of the infusion volume by means of balanced pressure in the microneedles. The devices with vacuum system also allow the microneedling process to be less painful and with less risk of bruising and vascular embolism. Most active ingredients used in digital microneedle-assisted drug delivery are obtained by sterile manipulation. Substances can be handled alone or in mixtures of synergistic substances.
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de Almeida Filippo, A., Bello, B.D., de Gusmão, P.R., Filippo, G.R. (2021). Digital Microneedling and Drug Delivery. In: Kalil, C.L.P.V., Campos, V. (eds) Drug Delivery in Dermatology . Springer, Cham. https://doi.org/10.1007/978-3-030-81807-4_12
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