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Fabrication and characterization of coated microneedle patches based on PEGDA for transdermal administration of metformin

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Abstract

Type 2 diabetes is one of the major challenges that the world is facing today. However, metformin (MET) as most type 2 diabetics’ first-line oral hypoglycemic drug may cause serious side effects such as gastrointestinal irritation and nausea which reduce the patients’ medication compliance. Therefore, the aim of the study was to design a safe and effective self-treatment device for the delivery of MET. Here, a kind of coated microneedle (MN) patches based on poly(ethylene glycol)diacrylate (PEGDA) were prepared by a two-step casting method and photopolymerization process for transdermal administration of MET. The needles wrapped with drug-loaded hyaluronic acid (HA) coating showed promising mechanical properties and drug delivery ability that allowed them to penetrate the skin barrier for rapid drug delivery, and they had no skin irritancy. The in vivo experiment of type 2 diabetic rats showed a satisfying hypoglycemic effect of the coated MN patches. The study shows that the prepared MN patches will be a potential method for the treatment of type 2 diabetes in the future.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by the Open Fund Project of Sanya Science and Education Innovation Park of Wuhan University of Technology (No. 2021KF0012), Guangdong Basic and Applied Basic Research Foundation (No. 2021B1515120091), and Technology Development Project of Shandong Weigao Orthopedic Materials Co., LTD (No. 20221h0074).

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Authors and Affiliations

  1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, People’s Republic of China

    Bo Zhou, Zhendong Guo, Peiwen Zhao, Hao Wang, Siyan Dong, Binbin Li & Xinyu Wang

  2. Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Xianhu Hydrogen Valley, Foshan, 528200, People’s Republic of China

    Xinyu Wang

  3. Hainan Institute, Wuhan University of Technology, Sanya, 572000, People’s Republic of China

    Bo Zhou, Binbin Li & Xinyu Wang

  4. Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan, 430070, People’s Republic of China

    Bo Zhou, Zhendong Guo, Peiwen Zhao, Hao Wang, Binbin Li & Xinyu Wang

  5. School of Foreign Languages, Wuhan University of Technology, Wuhan, 430070, People’s Republic of China

    Jing Yang

  6. Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China

    Bo Cheng & Xinyu Wang

  7. School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, UK

    Siyan Dong

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  1. Bo Zhou
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Contributions

Bo Zhou: conceptualization, methodology, investigation, formal analysis, data curation, visualization, writing—original draft, writing—review and editing; Zhendong Guo: methodology, investigation; Peiwen Zhao: methodology, supervision; Hao Wang: methodology, investigation; Siyan Dong: methodology, investigation; Bo Cheng: methodology, investigation; Jing Yang: methodology; Binbin Li: methodology, investigation, writing—review and editing, supervision; Xinyu Wang: conceptualization, supervision, project administration, funding acquisition, writing—review and editing.

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Correspondence to Binbin Li or Xinyu Wang.

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All animals were treated according to the standard guidelines approved by the Wuhan University of Technology Ethics Committee (SYXK 2017–0092). The experiments comply with the current laws of the country.

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Zhou, B., Guo, Z., Zhao, P. et al. Fabrication and characterization of coated microneedle patches based on PEGDA for transdermal administration of metformin. Drug Deliv. and Transl. Res. 14, 131–142 (2024). https://doi.org/10.1007/s13346-023-01387-8

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