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Induction of RANTES and CCR5 through NF-κB Activation via MAPK Pathway in Aged Rat Gingival Tissues

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Abstract

Chemokine and chemokine receptor expression in gingival tissues plays a central role in periodontal disease during aging. In the present study, we explored the modulation of chemokines and chemokine receptors expression in aging rat gingival tissues. In the 24-month-old (Old) rat gingival tissues, RANTES and CCR5 mRNA and protein levels were 2–4 fold increased over those of the 6-month-old (Young) rats. The Old rats had considerable enhancement of all three of the studied MAPK activities: extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. These results suggest that age-related increases in RANTES and CCR5 expression are associated with increased IκBα, nuclear NF-κB, and MAPK activity in gingival tissues.

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Authors and Affiliations

  1. Research Institute of Genetic Engineering, Pusan National University, 609-735, Busan, Korea

    Hyung Keun Kim

  2. Department of Oral Pathology School of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 602-739, Busan, Korea

    Hae Ryoun Park

  3. Department of Microbiology, School of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 602-739, Busan, Korea

    Kyoung Hee Sul & Jin Chung

  4. College of Pharmacy, Pusan National University, 609-735, Busan, Korea

    Hae Young Chung

Authors
  1. Hyung Keun Kim
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  2. Hae Ryoun Park
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  3. Kyoung Hee Sul
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  4. Hae Young Chung
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  5. Jin Chung
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Corresponding author

Correspondence to Jin Chung.

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Kim, H.K., Park, H.R., Sul, K.H. et al. Induction of RANTES and CCR5 through NF-κB Activation via MAPK Pathway in Aged Rat Gingival Tissues. Biotechnol Lett 28, 17–23 (2006). https://doi.org/10.1007/s10529-005-4681-6

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  • DOI: https://doi.org/10.1007/s10529-005-4681-6

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