Abstract
Several diagnostic methods for the evaluation and monitoring were used to find out the pro-inflammatory status, as well as incidence of sepsis in critically ill patients. One such recent method is based on investigating the genetic polymorphisms and determining the molecular and genetic links between them, as well as other sepsis-associated pathophysiologies. Identification of genetic polymorphisms in critical patients with sepsis can become a revolutionary method for evaluating and monitoring these patients. Similarly, the complications, as well as the high costs associated with the management of patients with sepsis, can be significantly reduced by early initiation of intensive care.
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Abbreviations
- ICU:
-
Intensive care unit
- HLA:
-
Human leukocyte Antigen
- NF-kB:
-
Nuclear transcription factor kappa B
- TNF-α:
-
Tumor necrosis factor alpha
- IL-6:
-
Interleukin 6
- IL-1β:
-
Interleukin 1 beta
- IL-1:
-
Interleukin 1
- IFN-γ:
-
Interferon gamma
- MODS:
-
Multile organ dysfunctions syndrome
- TLR:
-
Tol-like receptors
- SIRS:
-
Systeic inflammatory response syndrome
- MODS:
-
Muliple organ dysfunction syndrome
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David, V.L., Ercisli, M.F., Rogobete, A.F. et al. Early Prediction of Sepsis Incidence in Critically Ill Patients Using Specific Genetic Polymorphisms. Biochem Genet 55, 193–203 (2017). https://doi.org/10.1007/s10528-016-9785-2
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DOI: https://doi.org/10.1007/s10528-016-9785-2