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Dynamic Changes in Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) and its Gene Polymorphisms are Associated with Sepsis Prognosis

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Abstract

This study explored the association of sepsis prognosis with dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its polymorphisms. We enrolled 80 subjects with sepsis and 80 controls. Serum sTREM-1 was tested on days 1, 3, 5, 7, 10, and 14. PCR sequencing was performed to detect TREM-1 genetic variation on its four exons. sTREM-1 levels were significantly higher in the nonsurvivor than in the survivor group (p < 0.001), and those at each time point were the same (p ≤ 0.001). Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). However, there was no relationship between TREM-1 polymorphism and dynamic concentration of sTREM-1. Logistic regression showed that sTREM-1, APACHE II, and rs2234237 polymorphism are risk factors for prognosis. Dynamic changes in serum sTREM-1 and rs2234237 polymorphism could be used in sepsis prognosis assessment.

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Authors and Affiliations

  1. Department of Respiratory Diseases, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province, 572013, China

    Longxiang Su, Zhaoxu Jiang, Kun Xiao, Xin Zhang, Ming Li, Peng Yan & Lixin Xie

  2. Medical School, Nankai University, Tianjin, 300071, China

    Longxiang Su, Zhaoxu Jiang & Ming Li

  3. Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing, 100853, China

    Longxiang Su & Changting Liu

  4. Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, 100853, China

    Longxiang Su, Zhaoxu Jiang, Kun Xiao, Xin Zhang, Ming Li & Lixin Xie

  5. Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Cong Li

  6. Department of Medical Statistics, Chinese PLA General Hospital, Beijing, 100853, China

    Dan Feng

Authors
  1. Longxiang Su
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  2. Changting Liu
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  3. Cong Li
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  4. Zhaoxu Jiang
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  5. Kun Xiao
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  6. Xin Zhang
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  7. Ming Li
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  8. Peng Yan
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  9. Dan Feng
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  10. Lixin Xie
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Corresponding author

Correspondence to Lixin Xie.

Additional information

Dr. Longxiang Su and Dr. Changting Liu have contributed equally to this work.

The trial was registered under ClinicalTrial.gov identifier NCT01490424.

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Su, L., Liu, C., Li, C. et al. Dynamic Changes in Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) and its Gene Polymorphisms are Associated with Sepsis Prognosis. Inflammation 35, 1833–1843 (2012). https://doi.org/10.1007/s10753-012-9504-z

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  • DOI: https://doi.org/10.1007/s10753-012-9504-z

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