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Effects of Cocarboxylase in Amikacin-Induced Ototoxicity in Immature Animals

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Possible otoprotective properties of cocarboxylase were studied on the model of amikacin-induced ototoxicity in immature rabbits. Auditory function was evaluated by the short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests. Administration of cocarboxylase after modeling of amikacin-induced ototoxicity resulted in a decrease in the ABR peak I threshold and prevented damage to the outer hair cells.

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Authors and Affiliations

  1. Research Laboratory of Experimental Pediatric Otolaryngology, Moscow, Russia

    Yu. S. Ischanova & I. V. Rakhmanova

  2. Department of Physiology, Medical-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    I. N. D’yakonova

Authors
  1. Yu. S. Ischanova
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  2. I. V. Rakhmanova
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  3. I. N. D’yakonova
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Corresponding author

Correspondence to Yu. S. Ischanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 167, No. 2, pp. 204-208, February, 2019

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Ischanova, Y.S., Rakhmanova, I.V. & D’yakonova, I.N. Effects of Cocarboxylase in Amikacin-Induced Ototoxicity in Immature Animals. Bull Exp Biol Med 167, 250–254 (2019). https://doi.org/10.1007/s10517-019-04502-3

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  • DOI: https://doi.org/10.1007/s10517-019-04502-3

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