We studied the dynamics of maturation of the hearing function by records of short-term latent brainstem evoked potentials and the effect of amikacin on maturation of the hearing function. The peripheral compartment of the auditory analyzer matures sooner than the central structures. Amikacin in therapeutic doses exhibited an ototoxic effect on the peripheral compartment of the auditory analyzer without impairing its central structures.
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E. N. Baibarina, I. I. Ryumina, and V. V. Zubkov, Vopr. Praktich. Pediatr., 4, Suppl. 1, 5–6 (2009).
M. R. Bogomilskii, I. N. D’yakonova, and A. M. Tikhomirov, Vestn. Otorinolaringol., 4, 88 (1994).
B. M. Sagalovich and V. P. Klimov, Early Detection of Various Forms of Disorders in the Auditory Receptor and Auditory Nerve Functions by SSEP Recording. Methodological Recommendations [in Russian], Moscow (1990).
N. P. Shabalov, Neonatology [in Russian], Moscow (2006), vol. 1, pp. 567–582.
G. V. Yatsyk and E. P. Bombardirova, Prakt. Pediatr., No. 2, 6–9 (2009).
A. Berger, V. Kretzer, P. Gludovatz, et al., Acta Paediatr., 93, No. 3, 356–360 (2004).
A. G. Pettigrew and A. L. Morey, Brain Res., 430, No. 2, 267–276 (1987).
T. Saito, I. Yamamoto, X. L. Huang, et al., Hum. Exper. Toxicol., 18, No. 12, 718–723 (1999).
A. Siddiqi, D. A. Khan, F. A. Khan, and A. Razzaq, Singapore Med. J., 50, No. 5, 486–489 (2009).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 5, pp. 536–539, May, 2011
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D’yakonova, I.N., Rakhmanova, I.V., Tikhomirov, A.M. et al. Effects of Amikacin on Maturation of the Auditory Analyzer in Rabbits. Bull Exp Biol Med 151, 601–603 (2011). https://doi.org/10.1007/s10517-011-1392-y
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DOI: https://doi.org/10.1007/s10517-011-1392-y