Effect of successive administration vancomycin and amikacin in therapeutic doses on immature auditory organ was compared to single administration of the same drugs in chronic experiments on immature rabbits by recording of short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Drug administration always increased significantly the ABR peak I threshold. Ototoxic antibiotics did not change DPOAE, but selectively affected activity of outer hair cells. No enhancement of the ototoxic effects was observed after successive administration of the two antibiotics.
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References
Gvelesiani TG. Afe-related changes in otoacoustic emission. Vestn. Otorinolaringol. 2003;(6):11-13. Russian.
Goodman and Gilman’s Pharmacological Basis of Therapeutics. Moscow, 2006. P. 943-944. Russian.
D’yakonova IN, Ishanova YS, Rakhmanova IV, Sapozhnikov JM, Tikhomirov A.M.1, Sergeyeva E.G.1 Effect of netilmicin on the auditory analyzer (experimental study). Pediatr. Farmakol. 2011;8(5):70-75. Russian.
D’yakonova IN, Ishanova YS, Rakhmanova IV, Tikhomirov AM. Effect of gentamicin on the auditory analyzer in sexually immature animals. Bull. Exp. Biol. Med. 2014;158(7):61-65.
D’yakonova IN, Kamkina OV, Ishanova YS, Rakhmanova IV, Burmistrova DS. Auditory function in immature animals after two consecutive courses of ototoxic antibiotics. Bull. Exp. Biol. Med. 2015;159(4):415-419.
Diakonova IN, Rakhmanova IV, Burmistrova DS, Ishanova YuS. Investigation of the influence of vancomycin on the auditory function of immature animals. Vestn. Ross. Gos. Med. Univer. 2013;(4):75-79. Russian.
D’yakonova IN, Rakhmanova IV, Tikhomirov AM, Ishanova YS, Kotov RV. Effects of amikacin on maturation of the auditory analyzer in rabbits. Bull. Exp. Biol. Med. 2011;151(5):601-603.
Bhat YR, Lewis LE, K EV. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India. Ital. J. Pediatr. 2011;37:32. doi: 10.1186/1824-7288-37-32.
Durand S, Rideau Batista Novais A, Mesnage R, Combes C, Didelot M.N, Lotthé A, Filleron A, Baleine J, Cambonie G. Validation of nosocomial infection in neonatology: a new method for standardized surveillance. Am. J. Infect. Control. 2014;42(8):861-864.
Vella-Brincat JW, Begg EJ, Robertshawe BJ, Lynn AM, Borrie TL, Darlow BA. Are gentamicin and/or vancomycin associated with ototoxicity in the neonate? A retrospective audit. Neonatology. 2011;100(2):186-193.
Yurdakök M. Antibiotic use in neonatal sepsis. Turk. J. Pediatr. 1998;40(1):17-33.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 10, pp. 452-455, October, 2016
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D’yakonova, I.N., Kamkina, O.V., Rakhmanova, I.V. et al. Effect of Successive Administration of Vancomycin and Amikacin on Auditory Function of Immature Animals. Bull Exp Biol Med 162, 458–461 (2017). https://doi.org/10.1007/s10517-017-3639-8
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DOI: https://doi.org/10.1007/s10517-017-3639-8