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New insights into targeting mitochondria in ischemic injury

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Abstract

Stroke is the leading cause of adult disability and death worldwide. Mitochondrial dysfunction has been recognized as a marker of neuronal death during ischemic stroke. Maintaining the function of mitochondria is important for improving the survival of neurons and maintaining neuronal function. Damaged mitochondria induce neuronal cell apoptosis by releasing reactive oxygen species (ROS) and pro-apoptotic factors. Mitochondrial fission and fusion processes and mitophagy are of great importance to mitochondrial quality control. This paper reviews the dynamic changes in mitochondria, the roles of mitochondria in different cell types, and related signaling pathways in ischemic stroke. This review describes in detail the role of mitochondria in the process of neuronal injury and protection in cerebral ischemia, and integrates neuroprotective drugs targeting mitochondria in recent years, which may provide a theoretical basis for the progress of treatment of ischemic stroke. The potential of mitochondrial-targeted therapy is also emphasized, which provides valuable insights for clinical research.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (General Program 81971115, and 82071306), and the Beijing Key Laboratory (BZ0250).

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  1. Department of Neurology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China

    Jingjing Jia, Haiqiang Jin, Ding Nan, Weiwei Yu & Yining Huang

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Jia, J., Jin, H., Nan, D. et al. New insights into targeting mitochondria in ischemic injury. Apoptosis 26, 163–183 (2021). https://doi.org/10.1007/s10495-021-01661-5

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