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Protein Misfolding, Aggregation, and Autophagy After Brain Ischemia

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Abstract

Ischemic brain injury is a common disorder linked to a variety of diseases. Significant progress has been made in our understanding of the underlying mechanisms. Previous studies show that protein misfolding, aggregation, and multiple organelle damage are major pathological events in postischemic neurons. The autophagy pathway is the chief route for bulk degradation of protein aggregates and damaged organelles. The latest studies suggest that impairment of autophagy contributes to abnormal protein aggregation and organelle damages after brain ischemia. This article reviews recent studies of protein misfolding, aggregation, and impairment of autophagy after brain ischemia.

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Abbreviations

AP:

Autophagosome

AL:

Autolysosome

2VO:

Two-vessel occlusion with hypotension ischemia model

HSC70:

Heat-shock cognate protein 70

HSP40:

Heat-shock protein 40

ATG:

Autophagic gene-related protein

LC3:

Microtubule-associated protein light chain 3

DG:

Dentate gyrus

ER:

Endoplasmic reticulum

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Conflict of Interest

The authors declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed (see respective papers).

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Authors and Affiliations

  1. Shock, Trauma and Anesthesiology Research Center, Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA

    Tianfei Luo, Yujung Park, Xin Sun, Chunli Liu & Bingren Hu

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  1. Tianfei Luo
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  2. Yujung Park
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  3. Xin Sun
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Correspondence to Bingren Hu.

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Luo, T., Park, Y., Sun, X. et al. Protein Misfolding, Aggregation, and Autophagy After Brain Ischemia. Transl. Stroke Res. 4, 581–588 (2013). https://doi.org/10.1007/s12975-013-0299-5

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