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Apoptosis in Drosophila: which role for mitochondria?

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Abstract

It is now well established that the mitochondrion is a central regulator of mammalian cell apoptosis. However, the importance of this organelle in non-mammalian apoptosis has long been regarded as minor, mainly because of the absence of a crucial role for cytochrome c in caspase activation. Recent results indicate that the control of caspase activation and cell death in Drosophila occurs at the mitochondrial level. Numerous proteins, including RHG proteins and proteins of the Bcl-2 family that are key regulators of Drosophila apoptosis, constitutively or transiently localize in mitochondria. These proteins participate in the cell death process at different levels such as degradation of Diap1, a Drosophila IAP, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery. Here, we review these mitochondrial events that might have their counterpart in human.

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Acknowledgments

We are grateful to Tommaso Villa for his critical reading of the manuscript.

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  1. Laboratoire de Génétique et Biologie Cellulaire, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France

    Amandine Clavier, Aurore Rincheval-Arnold, Jessie Colin, Bernard Mignotte & Isabelle Guénal

  2. Laboratoire de Génétique Moléculaire et Physiologique, Ecole Pratique des Hautes Etudes, PSL Research University, 78180, Montigny-le-Bretonneux, France

    Amandine Clavier, Jessie Colin & Bernard Mignotte

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  1. Amandine Clavier
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  2. Aurore Rincheval-Arnold
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Correspondence to Isabelle Guénal.

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Clavier, A., Rincheval-Arnold, A., Colin, J. et al. Apoptosis in Drosophila: which role for mitochondria?. Apoptosis 21, 239–251 (2016). https://doi.org/10.1007/s10495-015-1209-y

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