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Successful Cognitive Aging and Health-Related Quality of Life in Younger and Older Adults Infected with HIV

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Abstract

Neurocognitive impairments commonly occur and adversely impact everyday functioning in older adults infected with HIV, but little is known about successful cognitive aging (SCA) and its health-related quality of life (HRQoL) correlates. Seventy younger (≤40 years) and 107 older (≥50 years) HIV+ adults, as well as age-matched seronegative comparison groups of younger (N = 48) and older (N = 77) subjects completed a comprehensive battery of neuropsychological, psychiatric, medical, and HRQoL assessments. SCA was operationalized as the absence of both performance-based neurocognitive deficits and self-reported symptoms (SCA-ANDS) as determined by published normative standards. A stair-step decline in SCA-ANDS was observed in accordance with increasing age and HIV serostatus, with the lowest rates of SCA-ANDS found in the older HIV+ group (19 %). In both younger and older HIV+ adults, SCA-ANDS was strongly related to better mental HRQoL. HIV infection has additive adverse effects on SCA, which may play a unique role in mental well-being among HIV-infected persons across the lifespan.

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References

  1. Prevention CfDCa. HIV/AIDS among persons 50 and older. Atlanta: Center for Disease Control and Prevention; 2008.

    Google Scholar 

  2. Prevention CfDCa. HIV surveillance report. Atlanta: Center for Disease Control and Prevention; 2008.

    Google Scholar 

  3. Gardner ID. The effect of aging on susceptibility to infection. Rev Infect Dis. 1980;2(5):801–10.

    Article  CAS  PubMed  Google Scholar 

  4. Ernst T, Chang L. Effect of aging on brain metabolism in antiretroviral-naive HIV patients. AIDS. 2004;18(Suppl 1):S61–7.

    Article  CAS  PubMed  Google Scholar 

  5. Jernigan TL, Gamst AC, Archibald SL, et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. Am J Psychiatry. 2005;162:1461–72.

    Article  PubMed  Google Scholar 

  6. Onen NF, Overton ET, Seyfried W, et al. Aging and HIV infection: a comparison between older HIV-infected persons and the general population. HIV Clin Trials. 2010;11(2):100–9.

    Article  PubMed  Google Scholar 

  7. Egger M, May M, Chene G, et al. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002;360(9327):119–29.

    Article  PubMed  Google Scholar 

  8. Rodriguez-Penney A, Iudicello J, Riggs P, et al. Co-morbidities in persons infected with HIV: increased burden with older age and negative effects on health-related quality of life. AIDS Patient Care STDs. 2013;27(1):5–16.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Cherner M, Ellis RJ, Lazzaretto D, et al. Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings. AIDS. 2004;18(Suppl 1):S27–34.

    Article  PubMed  Google Scholar 

  10. Valcour V, Shikuma C, Shiramizu B, et al. Higher frequency of dementia in older HIV-1 individuals: the Hawaii aging with HIV-1 cohort. Neurology. 2004;63:822–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Sacktor N, Skolasky R, Selnes OA, et al. Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals. J Neurovirol. 2007;3:203–9.

    Article  Google Scholar 

  12. Woods SP, Dawson MS, Weber E, Grant I, Group HNRCH. The sementic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection. J Clin Exp Neuropsychol. 2010;32(4):398–407.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Iudicello JE, Woods SP, Deutsch R, Grant I, Group HNRCH. Combined effects of aging and HIV infection on semantic verbal fluency: a view of the cortical hypothesis through the lens of clustering and switching. J Clin Exp Neuropsychol. 2012;34(5):476–88.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Hinkin CH, Hardy DJ, Mason KI, et al. Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse. AIDS. 2004;18(Suppl 1):S19–25.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Foley JM, Gooding AL, Thames AD, et al. Visuospatial and attentional abilities predict driving simulator performance among older HIV-infected adults. Am J Alzheimer’s Dis Dement. 2013;28(2):185–94.

    CAS  Google Scholar 

  16. Doyle K, Weber E, Atkinson JH, Grant I, Woods SP, Group HNRPH. Aging, prospective memory, and health-related quality of life in HIV infection. AIDS Behav. 2012;16(8):2309–18.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Tozzi V, Balestra P, Galgani S, et al. Neurocognitive performance and quality of life in patients with HIV infection. AIDS Res Hum Retrovir. 2003;19(8):643–52.

    Article  PubMed  Google Scholar 

  18. Osowiecki DM, Cohen RA, Morrow KM, et al. Neurocognitive and psychological contributions to quality of life in HIV-1-infected women. AIDS. 2000;14(10):1327–32.

    Article  CAS  PubMed  Google Scholar 

  19. Shimizu SM, Chow DC, Valcour V, et al. The impact of depressive symptoms on neuropsychological performance tests in HIV-infected adults: a study of the Hawaii aging with HIV cohort. World J AIDS. 2011;1(4):139–45.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Castellon SA, Hardy DJ, Hinkin CH, et al. Components of depression in HIV-1 infection: their differential relationship to neurocognitive performance. J Clin Exp Neuropsychol. 2006;28(3):420–37.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Daffner KR. Promoting successful cognitive aging: a comprehensive review. J Alzheimers Dis. 2010;19(4):1101–22.

    PubMed Central  PubMed  Google Scholar 

  22. Depp CA, Harmell A, Vahia IV. Successful cognitive aging. Curr Topics Behav Neurosci. 2012;10:35–50.

    Article  Google Scholar 

  23. Malaspina L, Woods SP, Moore DJ, et al. Successful cognitive aging in persons living with HIV infection. J Neurovirol. 2011;17:110–9.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Bassett SS, Folstein MF. Memory complaint, memory performance, and psychiatric diagnosis: a community study. J Geriatr Psychiatry Neurol. 1993;6:105–11.

    Article  CAS  PubMed  Google Scholar 

  25. Ponds RW, Commissaries KJ, Jolles J. Prevalence and covariates of subjective forgetfulness in a normal population in The Netherlands. Int J Aging Hum Dev. 1997;45:207–21.

    Article  CAS  PubMed  Google Scholar 

  26. McLaughlin SJ, Connell CM, Heeringa SG, Li LW, Roberts JS. Successful aging in the United States: prevalence estimates from a national sample of older adults. J Gerontol Ser B. 2010. doi:10.1093/geronb/gbp101;65B(2):216-226.

    Google Scholar 

  27. Sattler C, Toro P, Schönknecht P, Schröder J. Cognitive activity, education and socioeconomic status as preventive factors for mild cognitive impairment and Alzheimer’s disease. Psychiatry Res. 2012;196(1):90–5.

    Article  PubMed  Google Scholar 

  28. Glymour MM, Weuve J, Fay ME, Glass T, Berkman LF. Social ties and cognitive recovery after stroke: does social integration promote cognitive resilience? Neuroepidemiology. 2008;31(1):10–20.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Staudinger UM, Gluck J. Psychological wisdom research: commonalities and differences in a growing field. Annu Rev Psychol. 2011;62:215–41.

    Article  PubMed  Google Scholar 

  30. Hawkley LC, Berntson GG, Engeland CG, Marucha PT, Masi CM, Cacioppo JT. Stress, aging, and resilience: can accrued wear and tear be slowed? Can Psychol. 2005;46(3):115–25.

    Article  Google Scholar 

  31. Vahia I, Thompson WK, Depp CA, Allison MA, Jeste DV. Developing a dimensional model for successful cognitive and emotional aging. Int Psychogeriatr. 2012;24(4):515–23.

    Article  PubMed  Google Scholar 

  32. Ball K, Berch DB, Helmers KF, et al. Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA. 2002;288(18):2271–81.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Bosma H, van Boxtel MP, Ponds RW, Houx PJ, Burdorf A, Jolles J. Mental work demands protect against cognitive impairment: MAAS prospective cohort study. Exp Aging Res. 2003;29(1):33–45.

    Article  PubMed  Google Scholar 

  34. Antinori A, Arendt G, Becker JT, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;69(18):1789–99.

    Article  CAS  PubMed  Google Scholar 

  35. Woods SP, Rippeth JD, Frol AB, et al. Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. J Clin Exp Neuropsychol. 2004;26(6):759–78.

    Article  PubMed  Google Scholar 

  36. High KP, et al. HIV and Aging: State of knowledge and areas of critical need for research. A report to the NIH office of AIDS research by the HIV and aging working group. J Acquir Immune Defic Syndr. 2012;60:S1–18.

    Article  CAS  PubMed  Google Scholar 

  37. Moore RC, Moore DJ, Thompson WK, Vahia IV, Grant I, Jeste DV. A case-controlled study of successful aging in older adults with HIV. J Clin Psychiatry. 2013;14(5):e417–23.

    Article  Google Scholar 

  38. Castro KG, Ward JW, Slutsker L, et al. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults.

  39. Wechsler D. Wechsler Test of Adult Reading: WTAR: Psychological Corporation; 2001.

  40. Woods SP, Moran LM, Carey CL, et al. Prospective memory in HIV infection: is “remembering to remember” a unique predictor of self-reported medication management? Arch Clin Neuropsychol. 2008;23:257–70.

    Article  PubMed Central  PubMed  Google Scholar 

  41. McNair DM, Lorr M, Droppleman LF. Manual for the profile of mood states. San Diego: Educational and Industrial Testing Service; 1981.

    Google Scholar 

  42. Nyenhuis DL, Yamamoto C, Luchetta T, Terrien A, Parmentier A. Adult and geriatric normative data and validation of the profile of mood states. J Clin Psychiatry. 1999;55(1):76–86.

    Google Scholar 

  43. Hollingshead AB. Four factor index of social status. New Haven, Conn: Yale University; 1975.

    Google Scholar 

  44. Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc. 2002;8(3):448–60.

    Article  PubMed  Google Scholar 

  45. Robertson IH. A right hemisphere role in cognitive reserve. Neurobiol Aging. 2013. doi:10.1016/j.neurobiolaging.2013.11.028.

  46. Morgan E, Woods SP, Smith C, Weber E, Scott JC, Grant I. Lower cognitive reserve among individuals with syndromic HIV-associated neurocognitive disorders (HAND). AIDS Behav. 2012;16(8):2279–85.

    Article  PubMed Central  PubMed  Google Scholar 

  47. World Health Organization. Composite international diagnostic interview (CIDI, version 2.1). Geneva: World Health Organization; 1998.

  48. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). 4th ed. Washington, DC: American Psychiatric Association; 2000.

  49. Ware J, Sherbourne C. The MOS 26-item short-form health survey (SF-36): conceptual framework and item selection. Med Care. 1992;30:473–83.

    Article  PubMed  Google Scholar 

  50. Hsiung PC, Fang CT, Chang YY, Chen MY, Wang JD. Comparison of WHOQOL-bREF and SF-36 in patients with HIV infection. Qual Life Res. 2005;14(1):141–50.

    Article  PubMed  Google Scholar 

  51. Doyle YG, McKee M, Sherriff M. A model of successful ageing in British populations. Eur J Pub Health. 2012;22(1):71–6.

    Article  Google Scholar 

  52. Pereda M, Ayuso-Mateos JL, Gómez Del Barrio A, et al. Factors associated with neuropsychological performance in HIV-seropositive subjects without AIDS. Psychol Med. 2000;30(1):205–17.

    Article  CAS  PubMed  Google Scholar 

  53. Basso MR, Bornstein RA. Estimated premorbid intelligence mediates neurobehavioral change in individuals with HIV across 12 months. J Clin Exp Neuropsychol. 2000;22(2):208–18.

    Article  CAS  PubMed  Google Scholar 

  54. Yaffe K, Fiocco AJ, Lindquist K, et al. Predictors of maintaining cognitive function in older adults: The Health ABC study. Neurology. 2009;72:2029–35.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  55. Ellis RJ, Badiee J, Vaida F, et al. CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy. AIDS. 2011;25(14):1747–51.

    Article  CAS  PubMed  Google Scholar 

  56. Becker JT, Kingsley L, Mullen J, et al. Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men. Neurology. 2009;73:1292–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  57. McCutchan JA, Marquie-Beck JA, Fitzsimons CA, et al. Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder. Neurology. 2012;78(7):485–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  58. Fabbiani M, Ciccarelli N, Tana M, et al. Cardiovascular risk factors and carotid intima-media thickness are associated with lower cognitive performance in HIV-infected patients. HIV Med. 2013;14(3):136–44.

    Article  CAS  PubMed  Google Scholar 

  59. Yates KF, Sweat V, Yau PL, Turchiano MM, Convit A. Impact of metabolic syndrome on cognition and brain: a selected review of the literature. Arterioscler Thromb Vasc Biol. 2012;32(9):2060–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  60. Letendre SL, Zheng JC, Kaul M, et al. Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals. J Neurovirol. 2011;17(1):63–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  61. Everall IP, Trillo-Pazos G, Bell C, Mallory M, Sanders V, Masliah E. Amelioration of neurotoxic effects of HIV envelope protein gp 120 by fibroblast growth factor: a strategy for neuroprotection. J Neuropathol Exp Neurol. 2001;60(3):293–301.

    CAS  PubMed  Google Scholar 

  62. Loftis JM, Hauser P. Prevalence of psychiatric and substance use disorder co-morbidities in patients with hepatitis C. Curr Dir Psychiatry. 2008;28:211–25.

    Google Scholar 

  63. Fama R, Rosenbloom MJ, Sassoon SA, Thompson MA, Pfefferbaum A, Sullivan EV. Remote semantic memory for public figures in HIV infection, alcoholism, and their comorbidity. Alcohol. Clin. Exp. Res. 2011;35:265–76.

    Article  PubMed Central  PubMed  Google Scholar 

  64. Weber E, Blackstone K, Woods SP. Cognitive neurorehabilitation of HIV-associated neurocognitive disorders: a qualitative review and call to action. Neuropsychol Rev. 2013;23:81–98.

    Article  PubMed Central  PubMed  Google Scholar 

  65. Barnes DE, Cauley JA, Lui LY, et al. Women who maintain optimal cognitive function in older adults. J Am Geriatr Soc. 2007;55(2):259–64.

    Article  PubMed  Google Scholar 

  66. Rosenbloom MJ, Sullivan EV, Sassoon SA, et al. Alcoholism, HIV infection, and their comorbidity: factors affecting self-rated health-related quality of life. J Stud Alcohol Drugs. 2007;68:115–25.

    PubMed  Google Scholar 

  67. Sassoon SA, Rosenbloom MJ, Fama R, Sullivan EV, Pfefferbaum A. Selective neurocognitive deficits and poor life functioning are associated with significant depressive symptoms in alcoholism-HIV infection comorbidity. Psychiatry Res. 2012;199:102–10.

    Article  PubMed Central  PubMed  Google Scholar 

  68. Rourke SB, Grant I. The neurobehavioral correlates of alcoholism. In: Grant I, Adams K, editors. Neuropsychological assessment of neuropsychiatric and neuromedical disorders. New York: Oxford University Press; 2009.

    Google Scholar 

  69. Eom CS, Shin DW, Kim SY, et al. Impact of perceived social support on the mental health and health-related quality of life in cancer patients: results from a nationwide, multicenter survey in South Korea. Psychooncology. 2013;22(6):1289–90.

    Article  Google Scholar 

  70. Patterson TL, Shaw WS, Semple SJ, et al. Relationship of psychosocial factors to HIV disease progression. Ann Behav Med. 1996;18(1):30–9.

    Article  CAS  PubMed  Google Scholar 

  71. Hays RD, Shapiro MF. An overview of generic health-related quality of life measures for HIV research. Qual Life Res. 1992;1(2):91–7.

    Article  CAS  PubMed  Google Scholar 

  72. Justice AC. HIV and aging: time for a new paradigm. Curr HIV/AIDS Rep. 2010;7:69–76.

    Article  PubMed  Google Scholar 

  73. Chan N, Anstey KJ, Windsor TD, Luszcz MA. Disability and depressive symptoms in later life: the stress-buffering role of informal and formal support. Gerontology. 2010;57(2):180–9.

    Article  PubMed Central  PubMed  Google Scholar 

  74. Henry JD, Phillips LH, Ruffman T, Bailey PE. A meta-analytic review of age differences in theory of mind. Psychol Aging. 2013;28(3):826–39.

    Article  PubMed  Google Scholar 

  75. Lane TA, Moore DM, Batchelor J, Brew BJ, Cysique LA. Facial emotional processing in HIV infection: relation to neurocognitive and neuropsychiatric status. Neuropsychology. 2012;26(6):713–22.

    Article  PubMed  Google Scholar 

  76. Manly JJ, Patterson TL, Heaton RK, et al. The relationship between neuropsychological functioning and coping activity among HIV-positive men. AIDS Behav. 1997;1(2):81–91.

    Article  Google Scholar 

  77. Moore AD, Stambrook M, Peters LC. Coping strategies and adjustment after closed head-injury: a cluster analytical approach. Brain Inj. 1989;3:171–5.

    Article  CAS  PubMed  Google Scholar 

  78. Jeste DV, Savla GN, Thompson WK, et al. Association between older age and more successful aging: critical role of resilience and depression. Am J Psychiatry. 2013;170:188–96.

    Article  PubMed Central  PubMed  Google Scholar 

  79. Kahana E, Kahana B. Successful aging among people with HIV/AIDS. J Clin Epidemiol. 2001;54:S53–6.

    Article  PubMed  Google Scholar 

  80. Vance DE, Bayless H, Kempf MC, Keltner NL, Fazeli PL. Augmenting the components of successful aging. Aging Health. 2011;7:435–46.

    Article  Google Scholar 

  81. Vance DE, Burrage JW. Promoting successful cognitive aging in adults with HIV: strategies for intervention. J Gerontol Nurs. 2006;32(11):34–41.

    PubMed  Google Scholar 

  82. Vance DE, Eagerton G, Harnish B, McKie P, Fazeli PL. Cognitive prescriptions. J Gerontol Nurs. 2011;37(4):22–9.

    Article  PubMed  Google Scholar 

  83. Richards M, Deary IJ. A life course approach to cognitive reserve: a model for cognitive aging and development? Ann Neurol. 2005;58:612–22.

    Article  Google Scholar 

  84. Rabbitt P. Does it all go together when it goes? The nineteenth Bartlett Memorial Lecture. Q J Exp Psychol A. 1993;46A:385–434.

    Article  Google Scholar 

  85. Wilson RS, Barnes LL, Bennett DA. Assessment of lifetime participation in cognitively stimulating activities. In: Stern Y, editor. Cognitive reserve: theory and applications. New York, NY: Taylor and Francis; 2007. p. 159–72.

    Google Scholar 

  86. Schaie KW. Intellectual development in adulthood. New York, NY: Cambridge University Press; 1996.

    Google Scholar 

  87. Fritsch T, McClendon MJ, Smyth KA, Lerner AJ, Friedland RP, Larsen JD. Cognitive functioning in healthy aging: the role of reserve and lifestyle factors early in life. Gerontologist. 2007;47(3):307–22.

    Article  PubMed  Google Scholar 

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Acknowledgments

This research was supported by National Institutes of Health (NIH) Grants R01-MH073419 and P30-MH062512. Dr. R.C. Moore is supported by T32 MH019934. Dr. Fazeli is supported by R25-MH081482, R01-MH099987, and ID10-SD-057 from California HIV/AIDS Research Program (CHRP). The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or United States Government.

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  1. Department of Psychiatry (8231), University of California, San Diego, 220 Dickinson St., Suite B, San Diego, CA, 92103, USA

    Raeanne C. Moore, Pariya L. Fazeli, Dilip V. Jeste, David J. Moore, Igor Grant & Steven Paul Woods

  2. Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, San Diego, CA, USA

    Raeanne C. Moore & Dilip V. Jeste

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  1. Raeanne C. Moore
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The HIV Neurobehavioral Research Program (HNRP) Group

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The members of The HIV Neurobehavioral Research Program (HNRP) Group is listed in Appendix.

Appendix

Appendix

The San Diego HIV Neurobehavioral Research Program (HNRP) group is affiliated with the University of California, San Diego, the Naval Hospital, San Diego, and the Veterans Affairs San Diego Healthcare System, and it includes: Director: Igor Grant; Co-Directors: J. Hampton Atkinson, Ronald J. Ellis, and J. Allen McCutchan; Center Manager: Thomas D. Marcotte; Jennifer Marquie-Beck; Melanie Sherman; Neuromedical Component: Ronald J. Ellis (P.I.), J. Allen McCutchan, Scott Letendre, Edmund Capparelli, Rachel Schrier, Debra Rosario, Shannon LeBlanc; Neurobehavioral Component: Robert K. Heaton (P.I.), Steven Paul Woods, Mariana Cherner, David J. Moore, Erin E. Morgan, Matthew Dawson; Neuroimaging Component: Terry Jernigan (P.I.), Christine Fennema-Notestine, Sarah L. Archibald, John Hesselink, Jacopo Annese, Michael J. Taylor; Neurobiology Component: Eliezer Masliah (P.I.), Cristian Achim, Ian Everall (Consultant); Neurovirology Component: Douglas Richman (P.I.), David M. Smith; International Component: J. Allen McCutchan (P.I.); Developmental Component: Cristian Achim (P.I.), Stuart Lipton; Participant Accrual and Retention Unit: J. Hampton Atkinson (P.I.); Data Management Unit: Anthony C. Gamst (P.I.), Clint Cushman (Data Systems Manager); Statistics Unit: Ian Abramson (P.I.), Florin Vaida, Reena Deutsch, Anya Umlauf.

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Moore, R.C., Fazeli, P.L., Jeste, D.V. et al. Successful Cognitive Aging and Health-Related Quality of Life in Younger and Older Adults Infected with HIV. AIDS Behav 18, 1186–1197 (2014). https://doi.org/10.1007/s10461-014-0743-x

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