Abstract
This paper provides a selective review of instruments currently being employed to evaluate generic healthrelated quality of life in studies of persons with human immunodeficiency virus (HIV). Instruments examined include the Quality of Well-Being Scale, the HIV Overview of Problems/Evaluation System, the COOP Charts, and six Medical Outcomes Study-based measures: the SF-20, SF-30, AIDS-HAQ, SF-36, SF-38 and SF-56. Relative strengths and weaknesses of the measures are discussed.
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Bergner M. The Sickness Impact Profile (SIP). In: Wenger NK, Mattson ME, Furberg CD, et al., eds. Assessment of Quality of Life in Clinical Trials of Cardiovascular Therapies New York: Le Jacq Publishing Inc., 1984: 152–159.
Fischl MA, Richman DD, Hansen N, et al. The safety and efficacy of zidovudine (ZDV) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection: a doubleblind, placebo-controlled trial. Ann Intern Med 1990; 110: 727–737.
Williams JBW, Rabkin JG. The concurrent validity of items in the Quality-of-Life Index in a cohort of HIV-positive and HIV-negative gay men. Controlled Clin Trials 1991; 12: 129S-141S.
Kaplan RM, Anderson JP. A general health policy model: update and applications. Health Serv Res 1988; 23: 203–235.
Kaplan RM, Bush JW. Health-related quality of life measurement for evaluation research and policy analysis. Health Psychol 1982; 1: 61–80.
Kaplan RM, Anderson JP, Wu AW, et al. The quality of well-being scale: applications in AIDS, cystic fibrosis, and arthritis. Med Care 1989; 27: S27-S43.
Wu AW, Mathews WC, Brysk LT, et al. Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complex. J Acquir Immune Defic Syndr 1990; 3: 683–690.
Kaplan RM. Value for money in management of HIV: health-related quality of life. In: Maynard A, ed. Economic Aspects of HIV Management. London: Colwood House Medical Publications, 1991: 19–26.
Ganz PA, Schag CAC, Cheng H. Assessing the quality of life in newly-diagnosed breast cancer patients. J Clin Epidemiol 1990; 43: 75–86.
Schag CC, Heinrich RL, Ganz PA. Cancer Inventory of Problem Situations: An instrument for assessing cancer patients' rehabilitation needs. J Psychosoc Oncol 1983; 1: 11–24.
Schag CC, Heinrich RL, Aadland RL, et al. Assessing problems of cancer patients: psychometric properties of the Cancer Inventory of Problem Situations. Health Psychol 1990; 9: 83–102.
Schag CAC, Ganz PA, Kahn B, et al. HOPES: A quality of life tool for HIV. Paper presented at the meeting of the American Society of Clinical Oncology, San Diego, CA, May, 1992.
Landgraf JM, Nelson EC, Hays RD, et al. Assessing function: does it really make a difference? A preliminary evaluation of the acceptability and utility of the COOP function charts. In: Lipkin M, ed. Functional Status Measurement in Primary Care. New York: Springer-Verlag, 1990: 150–165.
Nelson EC, Landgraf JM, Hays RD, et al. The functional status of patients: how can it be measured in physicians' offices? Med Care 1990; 28: 1111–1126.
Wasson J, Keller A, Rubenstein L, et al. Benefits and obstacles of health status assessment in ambulatory settings: the clinician's point of view. Med Care 1992; (in press).
Lipkin M. ed Functional Status Measurement in Primary Care. New York: Springer-Verlag, 1990.
Tarlov AR, Ware JE, Greenfield S, et al. Medical Outcomes Study: An application of methods for evaluating the results of medical care. JAMA 1989; 262: 907–913.
Ware JE, Sherbourne CD, Davies AR. Developing and testing the MOS 20-item Short-Form health survey: a general population application. In: Stewart AL, Ware JE, eds. Measuring Functioning and Well-Being: The Medical Outcomes Study approach. Durham, NC: Duke University Press, 1992 (in press).
Stewart AL, Sherbourne C, Hays RD, et al. Summary and discussion of MOS measures. In: Stewart AL, Ware JE, eds. Measuring Functioning and Well-Being: The Medical Outcomes Study approach. Durham, NC: Duke University Press. 1992 (in press).
Stewart AL, Hays RD, Ware JE. The MOS shortform general health survey: reliability and validity in a patient population. Med Care 1988; 26: 724–735.
Stewart AL, Greenfield S, Hays RD, et al. Functional status and well-being of patients with chronic conditions. JAMA 1989; 262: 907–913.
Wells KB, Stewart AL, Hays RD, et al. The functioning and well-being of depressed patients: results from the Medical Outcomes Study. JAMA 1989; 262: 914–919.
Wachtel T, Piette J, Mor V, et al. Quality of life in persons with human immunodeficiency virus infection: measurement by the Medical Outcomes Study instrument. Ann Intern Med 1992; 116: 129–137.
Bindman A, Keane D, Lurie N. Measuring health changes among severely ill patients: the floor phenomenon. Med Care 1990; 28: 1142–1152.
Wu AW, Rubin HR, Mathews WC, et al. A health status questionnaire using 30 items from the Medical Outcomes Study: preliminary validation in persons with early HIV infection. Med Care 1991; 29: 786–798.
Cronbach LJ. Coefficient alpha and the internal structure of tests. Psychometrika 1951; 16: 297–334.
Wu A, Rubin HR, Mathews WC, et al. Functional status and well-being in a placebo-controlled trial of zidovudine in early ARC. Paper presented at the AIDS conference, San Francisco, CA, 21 June 1990.
Fries JF, Spitz PW, Kraines RG, et al. The dimensions of health outcomes: The Health Assessment Questionnaire, disability and pain scale. J Rheumatol 1980; 9: 789–793.
Lubeck DP, Fries JF. Health status among persons with HIV infection: a community-based study. Paper presented at the HIV-AIDS health Services Research and Delivery Conference, Miami, FL, December 1991.
Ware JE, Sherbourne CD. A 36-item short form health survey (SF-36): results from the Medical Outcomes Study. Med Care 1992; (in press).
Hays RD, Hayashi T. Beyond internal consistency reliability: rationale and user's guide for Multitrait Scaling Analysis Program on the microcomputer. Behavior Research Methods, Instruments & Computers 1990; 22: 167–175.
Berry SH, Bozette SA, Hays R, et al. Measuring health status in advanced HIV disease: results from a primary PCP prophylaxis trial. Paper presented at the Seventh International Conference on AIDS, Florence, Italy, 16–21 June 1991.
Hays RD, DiMatteo MR. A short-form measure of loneliness. J Pers Assess 1987; 51: 69–81.
Hadorn DC, Hays RD: Multitrait-multimethod analysis of health-related quaiity-of-life measures. Medc Care 1991; 29: 829–840.
Siu AL, Hays RD, Ouslander JG, et al. Measuring functioning and health in the very old. (submitted for publication).
Ware JE. Measures for a new era of health assessment: In: Stewart AL, Ware JE, eds. Measuring Functioning and Well-Being: the Medical Outcomes Study approach. Durham, NC: Duke University Press, 1992 (in press).
Jette AM, Cleary PD. Functional disability assessment. Phys Ther 1987; 67: 1854–1859.
Davies AR, Ware JE. Measuring Health Perceptions in the Health Insurance Experiment. Santa Monica, CA: The RAND Corporation, R-2711-HHS, 1981.
Hays RD, Stewart AL. The structure of self-reported health in chronic disease patients. Psychol Assessment: A Journal of Consulting and Clinical Psychology 1990; 2: 22–30.
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Preparation of this paper was supported in part by the World Health Organization (Regional Office for Europe), a grant from the Agency for Health Care Policy and Research (1 R01 HS06775) and by RAND. The views expressed are those of the authors and do not necessarily represent those of the sponsors or RAND.
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Hays, R.D., Shapiro, M.F. An overview of generic health-related quality of life measures for HIV research. Qual Life Res 1, 91–97 (1992). https://doi.org/10.1007/BF00439716
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DOI: https://doi.org/10.1007/BF00439716