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On the Mechanics of Transcatheter Aortic Valve Replacement

  • The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair
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Abstract

Transcatheter aortic valves (TAVs) represent the latest advances in prosthetic heart valve technology. TAVs are truly transformational as they bring the benefit of heart valve replacement to patients that would otherwise not be operated on. Nevertheless, like any new device technology, the high expectations are dampened with growing concerns arising from frequent complications that develop in patients, indicating that the technology is far from being mature. Some of the most common complications that plague current TAV devices include malpositioning, crimp-induced leaflet damage, paravalvular leak, thrombosis, conduction abnormalities and prosthesis-patient mismatch. In this article, we provide an in-depth review of the current state-of-the-art pertaining the mechanics of TAVs while highlighting various studies guiding clinicians, regulatory agencies, and next-generation device designers.

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Acknowledgements

The authors gratefully acknowledge funding from the American Heart Association (Grant No. 16GRNT30980070) and National Institutes of Health (Grant Nos. HL119824, HL104080, HL108240 and HL127570). The content is solely the responsibility of the authors and does not necessarily represent the official views of the American Heart Association or the National Institutes of Health.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research Institute, The Ohio State University, 473 W 12th Avenue, Columbus, OH, 43210, USA

    Lakshmi P. Dasi & Hoda Hatoum

  2. The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department of Biomedical Engineering, University of California, Irvine, CA, 92697, USA

    Arash Kheradvar, Ramin Zareian & S. Hamed Alavi

  3. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Wei Sun, Caitlin Martin, Thuy Pham, Qian Wang, Prem A. Midha, Vrishank Raghav & Ajit P. Yoganathan

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Correspondence to Lakshmi P. Dasi.

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Associate Editor Jane Grande-Allen oversaw the review of this article.

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Dasi, L.P., Hatoum, H., Kheradvar, A. et al. On the Mechanics of Transcatheter Aortic Valve Replacement. Ann Biomed Eng 45, 310–331 (2017). https://doi.org/10.1007/s10439-016-1759-3

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  • DOI: https://doi.org/10.1007/s10439-016-1759-3

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