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Scaffold-based Anti-infection Strategies in Bone Repair

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Abstract

Bone fractures and non-union defects often require surgical intervention where biomaterials are used to correct the defect, and approximately 10% of these procedures are compromised by bacterial infection. Currently, treatment options are limited to sustained, high doses of antibiotics and surgical debridement of affected tissue, leaving a significant, unmet need for the development of therapies to combat device-associated biofilm and infections. Engineering implants to prevent infection is a desirable material characteristic. Tissue engineered scaffolds for bone repair provide a means to both regenerate bone and serve as a base for adding antimicrobial agents. Incorporating anti-infection properties into regenerative medicine therapies could improve clinical outcomes and reduce the morbidity and mortality associated with biomaterial implant-associated infections. This review focuses on current animal models and technologies available to assess bone repair in the context of infection, antimicrobial agents to fight infection, the current state of antimicrobial scaffolds, and future directions in the field.

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Acknowledgments

The authors gratefully acknowledge funding from the National Institutes of Health (R01 AR062920, R01 AR062368).

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Authors and Affiliations

  1. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA

    Christopher T. Johnson & Andrés J. García

  2. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA

    Christopher T. Johnson

  3. School of Medicine, Emory University, Atlanta, GA, USA

    Christopher T. Johnson

  4. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Andrés J. García

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  1. Christopher T. Johnson
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Correspondence to Andrés J. García.

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Associate Editor Fei Wang oversaw the review of this article.

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Johnson, C.T., García, A.J. Scaffold-based Anti-infection Strategies in Bone Repair. Ann Biomed Eng 43, 515–528 (2015). https://doi.org/10.1007/s10439-014-1205-3

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