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On the Use of In Vivo Measured Flow Rates as Boundary Conditions for Image-Based Hemodynamic Models of the Human Aorta: Implications for Indicators of Abnormal Flow

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Abstract

The purpose of this study is to investigate how the imposition of personalized, non-invasively measured blood flow rates as boundary conditions (BCs) influences image-based computational hemodynamic studies in the human aorta. We extracted from 4D phase-contrast MRI acquisitions of a healthy human (1) the geometry of the thoracic aorta with supra-aortic arteries and (2) flow rate waveforms at all boundaries. Flow simulations were carried out, and the implications that the imposition of different BC schemes based on the measured flow rates have on wall shear stress (WSS)-based indicators of abnormal flow were analyzed. Our results show that both the flow rate repartition among the multiple outlets of the aorta and the distribution and magnitude of the WSS-based indicators are strongly influenced by the adopted BC strategy. Keeping as reference hemodynamic model the one where the applied BC scheme allowed to obtain a satisfactory agreement between the computed and the measured flow rate waveforms, differences in WSS-based indicators up to 49% were observed when the other BC strategies were applied. In conclusion, we demonstrate that in subject-specific computational hemodynamics models of the human aorta the imposition of BC settings based on non-invasively measured flow rate waveforms influences indicators of abnormal flow to a large extent. Hence, a BCs set-up assuring realistic, subject-specific instantaneous flow rate distribution must be applied when BCs such as flow rates are prescribed.

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Abbreviations

AAo:

Ascending aorta

BC:

Boundary condition

BCA:

Brachiocephalic artery

CFD:

Computational fluid dynamics

LCCA:

Left common carotid artery

LSA:

Left subclavian artery

OSI:

Oscillatory shear index

PC-MRI:

Phase-contrast magnetic resonance imaging

RRT:

Relative residence time

TAWSS:

Time-averaged wall shear stress

WSS:

Wall shear stress

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Authors and Affiliations

  1. Department of Mechanics, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129, Turin, Italy

    D. Gallo, F. Negri, D. Massai, M. A. Deriu & U. Morbiducci

  2. IBiTech-bioMMeda, Ghent University, Ghent, Belgium

    G. De Santis, P. Segers & B. Verhegghe

  3. IBFM, Research National Council, Milan, Italy

    D. Tresoldi & G. Rizzo

  4. CILEA, Consorzio Interuniversitario per l’Elaborazione e l’Automazione, Milan, Italy

    R. Ponzini

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  1. D. Gallo
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Correspondence to D. Gallo.

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Associate Editor Kerry Hourigan oversaw the review of this article.

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Gallo, D., De Santis, G., Negri, F. et al. On the Use of In Vivo Measured Flow Rates as Boundary Conditions for Image-Based Hemodynamic Models of the Human Aorta: Implications for Indicators of Abnormal Flow. Ann Biomed Eng 40, 729–741 (2012). https://doi.org/10.1007/s10439-011-0431-1

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