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Extraction and Separation Properties of Hydrophilic Compounds Using Novel Water-Holding Adsorbents Bonded with a Zwitter-Ionic Polymer

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Abstract

A novel water-holding adsorbent was synthesized by introducing a zwitter-ionic polymer to a hydrophilic methacrylate base resin. The retention abilities of the hydrophilic compounds on the adsorbents with and without cross-link in the zwitter-ionic functional groups were examined. The amount of held water on the non-cross-linked adsorbent was higher than that of the cross-linked one. The extraction efficiencies of the hydrophilic solutes on the adsorbents were evaluated by the solid phase extraction method. These adsorbents showed high affinity for nucleosides and glycosides, and good recoveries for such hydrophilic compounds in the solid-phase extraction were obtained. Furthermore, the retention properties of the hydrophilic solutes on the adsorbents were also evaluated by LC. The hydrophilic solutes were retained on these adsorbents by a partition mode based on a hydrophilic interaction. The retention factors of the hydrophilic solutes showed good correlation to their log P o/w (logarithm of octanol–water partition coefficient) and good separation based on hydrophilic interaction was obtained for nucleobases and nucleosides.

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Authors and Affiliations

  1. Products Planning & Development Department, R&D Center, Nippon Filcon Co., Ltd., 2220 Ohmaru, Inagi-shi, Tokyo, 206-8577, Japan

    Yoshinori Inoue, Waka Kamichatani & Mitsuru Saito

  2. College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai-shi, Aichi, 487-8501, Japan

    Yasuyuki Kobayashi & Atsushi Yamamoto

Authors
  1. Yoshinori Inoue
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  2. Waka Kamichatani
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  3. Mitsuru Saito
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  4. Yasuyuki Kobayashi
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  5. Atsushi Yamamoto
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Correspondence to Waka Kamichatani.

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Inoue, Y., Kamichatani, W., Saito, M. et al. Extraction and Separation Properties of Hydrophilic Compounds Using Novel Water-Holding Adsorbents Bonded with a Zwitter-Ionic Polymer. Chromatographia 73, 849–855 (2011). https://doi.org/10.1007/s10337-011-1965-y

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  • DOI: https://doi.org/10.1007/s10337-011-1965-y

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