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Adsorbents with a Covalently Bonded Polymer Layer for Hydrophilic Interaction Liquid Chromatography

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Abstract

Stationary phases based on silica modified with polyvinylpyridine and polyethyleneimine of different structures using 1,4-butanediol diglycidyl ether as a spacer are obtained. The study and comparison of the chromatographic properties of sorbents modified with polyamines and polyethylene glycol are performed using the Tanaka test for hydrophilic stationary phases and via the separation of model mixtures of sugars, amino acids, and water-soluble vitamins. It is shown that the nature and structure of the polymer in the functional layer affect both the selectivity and efficiency for polar compounds in hydrophilic interaction liquid chromatography mode.

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Funding

This work was supported by the Russian Science Foundation, project no. 20-13-00140 using equipment purchased at the expense of the Moscow University Development Program.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, 119991, Moscow, Russia

    A. S. Popov, G. S. Maksimov, O. A. Shpigun & A. V. Chernobrovkina

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  1. A. S. Popov
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  2. G. S. Maksimov
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  3. O. A. Shpigun
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  4. A. V. Chernobrovkina
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Corresponding author

Correspondence to A. V. Chernobrovkina.

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The authors declare that they have no conflicts of interest.

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Translated by V. Kudrinskaya

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Popov, A.S., Maksimov, G.S., Shpigun, O.A. et al. Adsorbents with a Covalently Bonded Polymer Layer for Hydrophilic Interaction Liquid Chromatography. J Anal Chem 77, 1173–1183 (2022). https://doi.org/10.1134/S1061934822090106

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  • DOI: https://doi.org/10.1134/S1061934822090106

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