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Hydrophilic interaction chromatography-type sorbent prepared by the modification of methacrylate-base resin with polyethyleneimine for solid-phase extraction of polar compounds

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Abstract

Hydrophilic interaction chromatography (HILIC)-type sorbents were newly developed for the solid-phase extraction (SPE) of polar compounds. Two methacrylate-base resins with different cross-linking monomers and pore properties were synthesized, and three polyethyleneimines (PEIs) with different molecular weights were modified onto each base resin. In both cases, PEIs with a molecular weight of 10,000 (PEI-10,000) exhibited the highest adsorption properties for polar compounds (uracil, uridine, adenosine, cytidine, and guanosine). To control the water-enriched layer at the surface of the PEI-10,000-modified sorbents, the additive amount of PEI-10,000 in the modified reaction was also optimized. When 10 times the amount of PEI-10,000 to each base resin was added, an improvement in adsorption property was observed. Moreover, the use of a nonaqueous sample solution (100% acetonitrile) during the sample loading process drastically improved adsorption, especially for uracil (about 80%) and adenosine (100%). These results indicate that the formation of a strong water-enriched layer at the surface of sorbents with an effective expression of hydrophilic interaction was an important factor in the adsorption properties of polar compounds in HILIC mode-SPE.

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Acknowledgements

This study was partly supported by JSPS KAKENHI Grant number 20K05571 (Grant-in-Aid for Scientific Research (C) for H. M.) and 19H02751 (Grand-in-Aid for Scientific Research (B) for N. T.). The authors also would like to thank Enago (www.enago.jp) for the English language reviews.

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Authors and Affiliations

  1. Department of Applied Chemistry, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, 470-0392, Japan

    Hiroya Murakami, Keisuke Iida, Yuki Oda, Yoshinori Inoue & Norio Teshima

  2. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo, 192-0392, Japan

    Tomonari Umemura

  3. Department of Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, 1-1 Minami-Ohsawa, Hachioji, Tokyo, 192-0397, Japan

    Hizuru Nakajima

  4. Gifu Pharmaceutical University, Daigaku-nishi, Gifu, 501–1196, Japan

    Yukihiro Esaka

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  1. Hiroya Murakami
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  2. Keisuke Iida
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Correspondence to Hiroya Murakami.

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Murakami, H., Iida, K., Oda, Y. et al. Hydrophilic interaction chromatography-type sorbent prepared by the modification of methacrylate-base resin with polyethyleneimine for solid-phase extraction of polar compounds. ANAL. SCI. 39, 375–381 (2023). https://doi.org/10.1007/s44211-022-00250-z

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  • DOI: https://doi.org/10.1007/s44211-022-00250-z

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