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Poroelastic analysis of interstitial fluid flow in a single lamellar trabecula subjected to cyclic loading

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Abstract

Trabecula, an anatomical unit of the cancellous bone, is a porous material that consists of a lamellar bone matrix and interstitial fluid in a lacuno-canalicular porosity. The flow of interstitial fluid caused by deformation of the bone matrix is believed to initiate a mechanical response in osteocytes for bone remodeling. In order to clarify the effect of the lamellar structure of the bone matrix—i.e., variations in material properties—on the fluid flow stimuli to osteocytes embedded in trabeculae, we investigated the mechanical behavior of an individual trabecula subjected to cyclic loading based on poroelasticity. We focused on variations in the trabecular permeability and developed an analytical solution containing both transient and steady-state responses for interstitial fluid pressure in a single trabecular model represented by a multilayered two-dimensional poroelastic slab. Based on the obtained solution, we calculated the pressure and seepage velocity of the interstitial fluid in lacuno-canalicular porosity, within the single trabecula, under various permeability distributions. Poroelastic analysis showed that a heterogeneous distribution of permeability produces remarkable variations in the fluid pressure and seepage velocity in the cross section of the individual trabecula, and suggests that fluid flow stimuli to osteocytes are mostly governed by the value of permeability in the neighborhood of the trabecular surfaces if there is no difference in the average permeability in a single trabecula.

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Acknowledgments

This study was partially supported by a Grant-in-Aid for Young Scientists (B) (25820011) from the Japan Society for the Promotion of Science (JSPS).

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Authors and Affiliations

  1. Department of Biomechanics, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Yoshitaka Kameo

  2. Department of Mechanical Engineering, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai-shi, Osaka, 599-8531, Japan

    Yoshitaka Kameo, Yoshihiro Ootao & Masayuki Ishihara

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  1. Yoshitaka Kameo
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  2. Yoshihiro Ootao
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  3. Masayuki Ishihara
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Correspondence to Yoshitaka Kameo.

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Kameo, Y., Ootao, Y. & Ishihara, M. Poroelastic analysis of interstitial fluid flow in a single lamellar trabecula subjected to cyclic loading. Biomech Model Mechanobiol 15, 361–370 (2016). https://doi.org/10.1007/s10237-015-0693-x

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  • DOI: https://doi.org/10.1007/s10237-015-0693-x

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