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Reference serum cystatin C levels in Japanese children

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Abstract

Background

Single measurements of serum cystatin C (cysC) concentration have generally been used to determine glomerular filtration rate (GFR) in adults. Since GFR varies to some extent among children, we attempted to determine reference serum cysC concentrations for Japanese children.

Methods

Serum cysC concentrations were determined by a latex particle-enhanced turbidimetric immunoassay in children who did not present with kidney disease or infectious disease, and the relationship between age and serum cysC level was assessed.

Results

We found that reference serum cysC levels gradually decreased during the first year after birth, thereafter becoming constant. Mean serum cysC concentration in children aged 1 year (0.76 ± 0.10 mg/L) was slightly higher than in children aged ≥2 years (0.70 ± 0.09 mg/L).

Conclusion

Our reference values will be applicable for screening renal function in Japanese children.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Aichi Children’s Health and Medical Center, 1-2 Osakada, Morioka-cho, Obu, Aichi, 474-8710, Japan

    Osamu Uemura, Katsumi Ushijima, Takuhito Nagai & Takuji Yamada

  2. Department of Clinical Laboratory, Aichi Children’s Health and Medical Center, Obu, Japan

    Hideki Hayakawa, Yayoi Nabeta, Yoshiko Shinkai, Kouichi Koike & Masaki Kuwabara

Authors
  1. Osamu Uemura
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  2. Katsumi Ushijima
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  3. Takuhito Nagai
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  4. Takuji Yamada
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  5. Hideki Hayakawa
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  6. Yayoi Nabeta
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  7. Yoshiko Shinkai
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  8. Kouichi Koike
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  9. Masaki Kuwabara
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Corresponding author

Correspondence to Osamu Uemura.

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Cite this article

Uemura, O., Ushijima, K., Nagai, T. et al. Reference serum cystatin C levels in Japanese children. Clin Exp Nephrol 14, 453–456 (2010). https://doi.org/10.1007/s10157-010-0314-z

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  • DOI: https://doi.org/10.1007/s10157-010-0314-z

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