Abstract
Octogenarians are more often viewed as high-risk surgical candidates. This increased risk is attributed to an age-related decline in physical function and reserve capacity coupled with the presence of various underlying diseases. There are no current guidelines or consensus on the optimal treatment strategy for this cohort of complex patients. The aim of this systematic review and meta-analysis was to compare the efficacy and safety of laparoscopic colorectal resection versus open colorectal resection in octogenarians. The meta-analysis was conducted following all aspects of the Cochrane Handbook for Systematic Reviews and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A systematic literature review was carried out using the following databases: MEDLINE, Embase, PubMed, the Cochrane Library, Google Scholar and OVID. Only studies comparing outcome of laparoscopic and open colorectal resections in the elderly population (≥80 years) were selected. The data collected included the patient demographics, interventions, observed outcome and sources of bias. When performing the statistical analysis, we used the odds ratio for categorical variables and the weighted mean difference for continuous variables. The results of this systematic review and pooled analysis demonstrated the safety and potential benefits of laparoscopic colorectal resection in octogenarians. LC can reduce the length of hospital stay, intraoperative blood loss, time to return of normal bowel function, and incidence of postoperative pneumonia, wound infection, and postoperative ileus.
Similar content being viewed by others
References
Nakamura T, Sato T, Miura H et al (2014) Feasibility and outcomes of surgical therapy in very elderly patients with colorectal cancer. Surg Laparosc Endosc Percutan Tech 24:85–88
Merlin F, Prochilo T, Tondulli L, Kildani B, Beretta GD (2008) Colorectal cancer treatment in elderly patients: an update on recent clinical studies. Clin Colorectal Cancer 7:357–363
Cheung HY, Chung CC, Fung JT, Wong JC, Yau KK, Li MK (2007) Laparoscopic resection for colorectal cancer in octogenarians: results in a decade. Dis Colon Rectum 50:1905–1910
Kozman MA (2012) Laparoscopic colorectal surgery is safe and may be beneficial in patients eighty years of age and over. Open J Gastroenterol 2:76–80
Seshadri PA, Mamazza J, Schlachta CM, Cadeddu MO, Poulin EC (2001) Laparoscopic colorectal resection in octogenarians. Surg Endosc 15:802–805
Soma T, Sugano M, Kawasaki C, Tsuji M, Fukui I (2014) Colorectal resection in nonagenarians: effectiveness of laparoscopic surgery. Asian J Endosc Surg 7:222–226
Hatakeyama T, Nakanishi M, Murayama Y et al (2013) Laparoscopic resection for colorectal cancer improves short-term outcomes in very elderly colorectal cancer patients. Surg Laparosc Endosc Percutan Tech 23:532–535
Folprecht G, Cunningham D, Ross P et al (2004) Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol 15:1330–1338
Grailey K, Markar SR, Karthikesalingam A, Aboud R, Ziprin P, Faiz O (2013) Laparoscopic versus open colorectal resection in the elderly population. Surg Endosc 27:19–30
Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5:13
Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions Version 5.1.0. The Cochrane Collaboration, Available from www.cochrane-handbook.org
Stewart BT, Stitz RW, Lumley JW (1999) Laparoscopically assisted colorectal surgery in the elderly. Br J Surg 86:938–941
Vignali A, Di Palo S, Tamburini A, Radaelli G, Orsenigo E, Staudacher C (2005) Laparoscopic versus open colectomies in octogenarians: a case-matched control study. Dis Colon Rectum 48:2070–2075
Kurian AA, Suryadevara S, Vaughn D et al (2010) Laparoscopic colectomy in octogenarians and nonagenarians: a preferable option to open surgery? J Surg Educ 67:161–166
Lian L, Kalady M, Geisler D, Kiran RP (2010) Laparoscopic colectomy is safe and leads to a significantly shorter hospital stay for octogenarians. Surg Endosc 24:2039–2043
Issa N, Grassi C, Melki Y, Powsner E, Dreznik Z (2011) Laparoscopic colectomy for carcinoma of the colon in octogenarians. J Gastrointest Surg 15:2011–2015
Pinto RA, Ruiz D, Edden Y, Weiss EG, Nogueras JJ, Wexner SD (2011) How reliable is laparoscopic colorectal surgery compared with laparotomy for octogenarians? Surg Endosc 25:2692–2698
Hinoi T, Kawaguchi Y, Hattori M et al (2014) Laparoscopic versus open surgery for colorectal cancer in elderly patients: a multicenter matched case–control study. Ann Surg Oncol 22:2040–2050
Vallribera VF, Landi F, Espin BE et al (2014) Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients. Surg Endosc 28:3373–3378
Fielding LP, Phillips RK, Hittinger R (1989) Factors influencing mortality after curative resection for large bowel cancer in elderly patients. Lancet 1:595–597
Brooks-Brunn JA (1997) Predictors of postoperative pulmonary complications following abdominal surgery. Chest 111:564–571
Fujita T, Sakurai K (1995) Multivariate analysis of risk factors for postoperative pneumonia. Am J Surg 169:304–307
Garibaldi RA, Britt MR, Coleman ML, Reading JC, Pace NL (1981) Risk factors for postoperative pneumonia. Am J Med 70:677–680
Frasson M, Braga M, Vignali A, Zuliani W, Di Carlo V (2008) Benefits of laparoscopic colorectal resection are more pronounced in elderly patients. Dis Colon Rectum 51:296–300
Zollinger A, Krayer S, Singer T et al (1997) Haemodynamic effects of pneumoperitoneum in elderly patients with an increased cardiac risk. Eur J Anaesthesiol 14:266–275
Song SP, Lian L, He XS, Wu XJ (2012) Laparoscopic colorectomy versus open colorectomy for elderly patients over 80 years old: a meta-analysis of safety and efficacy. Zhonghua Wei Chang Wai Ke Za Zhi 15:1027–1031
Zhu Q, Mao Z, Jin J, Deng Y, Zheng M, Yu B (2010) The safety of CO2 pneumoperitoneum for elderly patients during laparoscopic colorectal surgery. Surg Laparosc Endosc Percutan Tech 20:54–57
Hida K, Yamaguchi T, Hata H et al (2009) Risk factors for complications after laparoscopic surgery in colorectal cancer patients: experience of 401 cases at a single institution. World J Surg 33:1733–1740
Gill TM, Allore HG, Gahbauer EA, Murphy TE (2010) Change in disability after hospitalization or restricted activity in older persons. JAMA 304:1919–1928
Lamont CT, Sampson S, Matthias R, Kane R (1983) The outcome of hospitalization for acute illness in the elderly. J Am Geriatr Soc 31:282–288
Jayne DG, Thorpe HC, Copeland J, Quirke P, Brown JM, Guillou PJ (2010) Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer. Br J Surg 97:1638–1645
Sheridan J, Walsh P, Kevans D et al (2014) Determinants of short- and long-term survival from colorectal cancer in very elderly patients. J Geriatr Oncol 5:376–383
Acknowledgments
The present study was supported by grants from the Development Center for Medical Science and Technology, Ministry of Health, PR China (No. W2013R02) and Shanxi Cancer Hospital and Institute (No. 201102).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
For this type of study formal consent is not required.
Additional information
Y. Li and S. Wang have contributed equally to this work.
Rights and permissions
About this article
Cite this article
Li, Y., Wang, S., Gao, S. et al. Laparoscopic colorectal resection versus open colorectal resection in octogenarians: a systematic review and meta-analysis of safety and efficacy. Tech Coloproctol 20, 153–162 (2016). https://doi.org/10.1007/s10151-015-1419-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10151-015-1419-x