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The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma

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International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Aurora B is a serine–threonine kinase and chromosomal passenger protein involved in the control of chromosome assembly and segregation during mitosis. Aberrant expression of Aurora B has been reported in some tumors, including lung and hepatocellular carcinoma (HCC). We investigated the role of Aurora B expression in both HCC and matched adjacent non-tumor tissue.

Methods

Sixty-three patients with HCC who underwent hepatic resection were enrolled in this study. Aurora B expression in tumor and non-tumor tissue was examined by use of quantitative reverse transcription-polymerase chain reaction. The patients were divided into high and low gene expression groups by median value, and clinicopathological data were compared between the two groups.

Results

Aurora B expression was significantly higher in tumor tissue than in non-cancerous tissue (P < 0.001). Disease-free survival was not significantly different between groups with high and low expression in the tumor tissues. For non-tumor tissues, disease-free survival of the low-expression group was significantly better than that of the high-expression group (P < 0.05). The gene expression level of Aurora B correlated with results from liver function tests, for example prothrombin time.

Conclusion

Aurora B expression in non-cancerous tissues may be a prognostic factor for HCC.

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Abbreviations

HCC:

Hepatocellular carcinoma

RT-PCR:

Reverse transcription-polymerase chain reaction

CPC:

Chromosomal passenger complex

INCENP:

Inner centromere protein

GAPDH:

Glyceraldehyde-3-phosphate dehydrogenase

AST:

Aspartate aminotransferase

ALT:

Alanine transaminase

WBC:

White blood cell

PT:

Prothrombin time

LF:

Liver fibrosis

CH:

Chronic hepatitis

LC:

Liver cirrhosis

ICGR15:

Indocyanine green retention rate at 15 min

AFP:

Alpha-fetoprotein

DCP:

Des-gamma-carboxy prothrombin

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Acknowledgments

This work was supported in part by Grants-in-Aid for Scientific Research (B) (20390359) and for Scientific Research (C) (22591506), and Grants-in-Aid for Challenging Exploratory Research (22659233 and 22659243) from the Japan Society for the Promotion of Science. This work was also supported in part by a grant from the Cancer Research Project involving cooperation by TAIHO Pharmaceutical Co. and the University of Tokushima.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, The University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan

    Lkhagva-Ochir Tovuu, Tohru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Hiroki Mori, Jun Hanaoka, Mami Kanamoto, Koji Sugimoto, Yu Saito, Shinichiro Yamada, Michihito Asanoma & Mitsuo Shimada

Authors
  1. Lkhagva-Ochir Tovuu
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  2. Tohru Utsunomiya
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  3. Satoru Imura
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  4. Yuji Morine
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  5. Tetsuya Ikemoto
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  6. Yusuke Arakawa
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  7. Hiroki Mori
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  8. Jun Hanaoka
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  9. Mami Kanamoto
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  10. Koji Sugimoto
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  11. Yu Saito
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  12. Shinichiro Yamada
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  13. Michihito Asanoma
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  14. Mitsuo Shimada
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Corresponding author

Correspondence to Satoru Imura.

Additional information

L.-O. Tovuu and T. Utsunomiya contributed equally to this study.

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Tovuu, LO., Utsunomiya, T., Imura, S. et al. The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma. Int J Clin Oncol 19, 622–628 (2014). https://doi.org/10.1007/s10147-013-0593-y

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  • DOI: https://doi.org/10.1007/s10147-013-0593-y

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