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Proton magnetic resonance spectroscopy (MRS) of metastatic brain tumors: variations of metabolic profile

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Abstract

Background

Spectroscopic imaging can be helpful for the noninvasive identification of parenchymal brain tumors. The objective of the present study was the characterization of the metabolic profile of intracranial metastases, based on proton magnetic resonance spectroscopy (MRS).

Methods

One hundred and four metastatic brain tumors were evaluated by long-echo (TR, 2000 ms; TE, 136 ms) single-voxel volume-selected proton MRS. In 83 patients the tumor fraction within the MRS voxel constituted more than 50%.

Results

Compared to normal brain, the tumors showed statistically significant decreases of N-acetylaspartate (P < 0.0001), creatine (P < 0.0001), and the [NAA]/choline-containing compounds ratio (P < 0.0001), increases of [Cho] (P < 0.0001) and the mobile lipids/[Cr] ratio (P < 0.0001) and the lactate/[Cr] ratio (P < 0.05), and the more frequent presence of [Lip] (P < 0.0001) and [Lac] (P < 0.0001) resonances. However, the majority of these differences were lost when data for patients whose tumor fraction within the MRS voxel constituted less than 50% were analyzed separately. Determination of the predominant metabolite peak on the MR spectrum [NAA, Cho, Lip] permitted us to define three general metabolic patterns of brain metastases, which, showed statistically significant associations with the size of the neoplasm (P < 0.001), type of its contrast enhancement (P < 0.01), and the extent of perilesional edema (P < 0.05).

Conclusion

Proton MRS can define metabolically different subsets of metastatic brain tumors, and these characteristics should be taken into consideration during the differential diagnosis of parenchymal brain lesions.

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Authors and Affiliations

  1. Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Mikhail F. Chernov, Motohiro Hayashi, Masahiro Izawa & Tomokatsu Hori

  2. Department of Neuroradiology, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan

    Yuko Ono

Authors
  1. Mikhail F. Chernov
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  2. Motohiro Hayashi
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  3. Masahiro Izawa
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  4. Yuko Ono
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  5. Tomokatsu Hori
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Corresponding author

Correspondence to Mikhail F. Chernov.

Additional information

The results of this study were presented in part during 64th Annual Meeting of the Japan Neurosurgical Society, October 5–7, 2005, Yokohama, Japan

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Chernov, M., Hayashi, M., Izawa, M. et al. Proton magnetic resonance spectroscopy (MRS) of metastatic brain tumors: variations of metabolic profile. Int J Clin Oncol 11, 375–384 (2006). https://doi.org/10.1007/s10147-006-0589-y

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  • DOI: https://doi.org/10.1007/s10147-006-0589-y

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