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Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives

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Abstract

Proton magnetic resonance spectroscopy (1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absentN-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neoplasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of1HMRS and future applications are reviewed.

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Authors and Affiliations

  1. Neuroradiology Department, Scientific Institute S, Raffaele Hospital, Via Olgettina 60, I-20132, Milan, Italy

    Andrea Falini, Giovanna Calabrese, Daniela Origgi, Susanna Lipari, Fabio Triulzi & Giuseppe Scotti

  2. Neurosurgery Institute, Scientific Institute S, Raffaele Hospital, University of Milan, Milan, Italy

    Marco Losa

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  1. Andrea Falini
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  2. Giovanna Calabrese
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  3. Daniela Origgi
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  4. Susanna Lipari
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  5. Fabio Triulzi
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  6. Marco Losa
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  7. Giuseppe Scotti
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Falini, A., Calabrese, G., Origgi, D. et al. Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives. J Neurol 243, 706–714 (1996). https://doi.org/10.1007/BF00873976

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  • DOI: https://doi.org/10.1007/BF00873976

Key words

Magnetic resonance spectroscopy

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