Skip to main content

Advertisement

SpringerLink
Log in

The relationship of PADI4_94 polymorphisms with the morbidity of rheumatoid arthritis in Caucasian and Asian populations: a meta-analysis and system review

  • Review Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease that is characterized by chronic, destructive, and debilitating arthritis. Peptidyl arginine deiminase type 4 (PADI4) polymorphisms (PADI4_94) have been reported to play a vital role in the disease. Nevertheless, the results were inconclusive. An electronic search of Embase, PubMed, CNKI, and WANFANG Date was performed to the identification of relevant studies published from 2003 to 2017. A total of 20 studies were enrolled as being eligible for analysis. In overall analysis, we had found a significant correlation between the PADI4_94 polymorphisms and RA under T vs. C (OR = 1.05, 95% CI 1.01–1.08, P = 0.01). Nevertheless, there were no significant associations under other four genetic models. In the subgroup analysis, we had observed the similar results in Asian population (T vs. C: OR = 1.11, 95% CI 1.05–1.17, P = 0.001), whereas no significant difference were observed in Caucasian population under any genetic model (P > 0.05). In conclusion, our meta-analysis demonstrated that the PADI4_94 polymorphisms might contribute to RA susceptibility especially in Asian populations but not in Caucasian populations. More well-designed studies with larger sample size are still required to further elucidate the relationship.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Gabriel SE, Michaud K (2009) Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther 11(3):229. https://doi.org/10.1186/ar2669

    Article  PubMed  PubMed Central  Google Scholar 

  2. Liu L, Xu X, Xu N, Wang L (2017) Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study. Health Qual Life Outcomes 15(1):149. https://doi.org/10.1186/s12955-017-0725-6

    Article  PubMed  PubMed Central  Google Scholar 

  3. Knevel R, Huizinga T, Kurreeman F (2017) Genomic influences on susceptibility and severity of rheumatoid arthritis. Rheum Dis Clin N Am 43(3):347–361. https://doi.org/10.1016/j.rdc.2017.04.002

    Article  Google Scholar 

  4. Jamshidi A, Gharibdoost F, Vojdanian M, Soroosh SG, Soroush M, Ahmadzadeh A, Nazarinia MA, Mousavi M, Karimzadeh H, Shakibi MR, Rezaieyazdi Z, Sahebari M, Hajiabbasi A, Ebrahimi AA, Mahjourian N, Rashti AM (2017) A phase III, randomized, two-armed, double-blind, parallel, active controlled, and non-inferiority clinical trial to compare efficacy and safety of biosimilar adalimumab (CinnoRA(R)) to the reference product (Humira(R)) in patients with active rheumatoid arthritis. Arthritis Res Ther 19(1):168. https://doi.org/10.1186/s13075-017-1371-4

    Article  PubMed  PubMed Central  Google Scholar 

  5. Woo P, Colbert RA (2009) An overview of genetics of paediatric rheumatic diseases. Best Pract Res Clin Rheumatol 23(5):589–597. https://doi.org/10.1016/j.berh.2009.08.001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, RACI consortium, GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, de Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506(7488):376–381. https://doi.org/10.1038/nature12873

    Article  CAS  PubMed  Google Scholar 

  7. Goulielmos GN, Zervou MI, Myrthianou E, Burska A, Niewold TB, Ponchel F (2016) Genetic data: the new challenge of personalized medicine, insights for rheumatoid arthritis patients. Gene 583(2):90–101. https://doi.org/10.1016/j.gene.2016.02.004

    Article  CAS  PubMed  Google Scholar 

  8. Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, Ohtsuki M, Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K (2003) Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 34(4):395–402. https://doi.org/10.1038/ng1206

    Article  CAS  PubMed  Google Scholar 

  9. Hisa K, Yanagimachi MD, Naruto T et al (2017) PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis. PLoS One 12(2):e171961

    Article  Google Scholar 

  10. Too CL, Murad S, Dhaliwal JS, Larsson PT, Jiang X, Ding B, Alfredsson L, Klareskog L, Padyukov L (2012) Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis. Arthritis Res Ther 14(6):R250. https://doi.org/10.1186/ar4093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Cheng J, Zhang H, Zhuang C, Liu R (2012) Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis. J Rheumatol 39(6):1159–1165. https://doi.org/10.3899/jrheum.120007

    Article  CAS  PubMed  Google Scholar 

  12. Burr ML, Naseem H, Hinks A, Eyre S, Gibbons LJ, Bowes J, Wilson AG, Maxwell J, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Thomson W, Worthington J, BIRAC Consortium, YEAR Consortium, Barton A (2010) PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population. Ann Rheum Dis 69(4):666–670. https://doi.org/10.1136/ard.2009.111294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hou S, Gao GP, Zhang XJ et al (2013) PADI4 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis. Mod Rheumatol 23(1):50–60. https://doi.org/10.3109/s10165-012-0639-4

    Article  PubMed  Google Scholar 

  14. Zhang S, Wang XB, Han YD et al (2017) Certain polymorphisms in SP110 gene confer susceptibility to tuberculosis: a comprehensive review and updated meta-analysis. Yonsei Med J 58(1):165–173. https://doi.org/10.3349/ymj.2017.58.1.165

    Article  PubMed  Google Scholar 

  15. Liu J, Yang FM, Zhang PL, Li R, Wang YJ (2012) The relationship of PADI4 polymorphism with rheumatic arthritis in Han, Tibetan, Hui people in the plateau area. Chin J Gerontol 32(18):3881–3883

    CAS  Google Scholar 

  16. Liang Y (2008) Association between rheumatoid arthritis and single nucleotide polymorphisms of PADl4

  17. Feng ZJ, Wen HF, Niu HZ, Liang Y, Zhang SL (2010) The relationship of PADI4 polymorphism with rheumatic arthritis in He Bei province. The fifth clinical laboratory academic conference of three provinces and two cities in north China. Area:286–291

  18. Shi HX, Qqin L, Li XP et al (2010) Association of polymorphism of peptidylarginine deaminase-4 gene and rheumatoid arthritis. Chin J Rheumatol 14(5):336–339

    CAS  Google Scholar 

  19. Cui LF, Yuan W, Yang WH et al (2011) Association of polymorphism of peptidylarginine deiminase4 (PADI4) gene with rheumatoid arthritis and anti-cyclic citrullinated peptide antibody. Chin J Basic Med Tradit Chin Med 17(6):630–632

    CAS  Google Scholar 

  20. Li Q, Lin KQ, Li Q et al (2013) Association of polymorphisms of PTPN22 and PADl4 genes with rheumatoid arthritis in Yunnan. Chin J Med Gent 30(1):111–115

    CAS  Google Scholar 

  21. Zhang Y (2015) Association of single nucleotide polymorphisms of PADl4-94T/C gene with rheumatoid arthritis in Chinese Han people in Liaoning province.: China Medical University

  22. Xu PS, Shao FM, Sun CY, Shu WS, Hu H (2011) Association of peptidylarginine deiminase 4 -94 and 104 single nucleotide polymorphisms with rheumatoid arthritis. Chin J Prev Contr Chron Dis 19(05):489–491

    CAS  Google Scholar 

  23. Chen R, Wei Y, Cai Q, Duan S, Ren D, Shen J, He D, Fang M, Lv K, Cheng N, Sun S (2011) The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population. Rheumatol Int 31(12):1631–1634. https://doi.org/10.1007/s00296-010-1519-x

    Article  CAS  PubMed  Google Scholar 

  24. Takata Y, Inoue H, Sato A, Tsugawa K, Miyatake K, Hamada D, Shinomiya F, Nakano S, Yasui N, Tanahashi T, Itakura M (2008) Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies. J Hum Genet 53(2):163–173. https://doi.org/10.1007/s10038-007-0232-4

    Article  CAS  PubMed  Google Scholar 

  25. Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD (2005) Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet 77(6):1044–1060. https://doi.org/10.1086/498651

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Martinez A, Valdivia A, Pascual-Salcedo D, Lamas JR, Fernández-Arquero M, Balsa A, Fernández-Gutiérrez B, de la Concha EG, Urcelay E (2005) PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population. Rheumatology (Oxford) 44(10):1263–1266. https://doi.org/10.1093/rheumatology/kei008

    Article  CAS  Google Scholar 

  27. Goh LL, Yong MY, See WQ et al (2017) NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese. Rheumatol Int 37(8):1295–1302. https://doi.org/10.1007/s00296-017-3762-x

    Article  CAS  PubMed  Google Scholar 

  28. Costenbader KH, Chang SC, De Vivo I, Plenge R, Karlson EW (2008) Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. Arthritis Res Ther 10(3):R52. https://doi.org/10.1186/ar2421

    Article  PubMed  PubMed Central  Google Scholar 

  29. Hegab MM, Abdelwahab AF, El-Sayed YA et al (2016) CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians. Hum Immunol 77(6):522–526. https://doi.org/10.1016/j.humimm.2016.04.018

    Article  CAS  PubMed  Google Scholar 

  30. Ikari K, Kuwahara M, Nakamura T, Momohara S, Hara M, Yamanaka H, Tomatsu T, Kamatani N (2005) Association between PADI4 and rheumatoid arthritis: a replication study. Arthritis Rheum 52(10):3054–3057. https://doi.org/10.1002/art.21309

    Article  CAS  PubMed  Google Scholar 

  31. Ben HH, Zemni R, Bouagina E et al (2012) Lack of association between PADI4 polymorphisms and rheumatoid arthritis in the Tunisian population. Joint Bone Spine 79(3):329–330

    Article  Google Scholar 

  32. Pozsgay J, Szekanecz Z, Sarmay G (2017) Antigen-specific immunotherapies in rheumatic diseases. Nat Rev Rheumatol

  33. Lee YH, Bae SC (2016) Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis. Clin Rheumatol 35(4):961–971. https://doi.org/10.1007/s10067-015-3098-4

    Article  PubMed  Google Scholar 

Download references

Funding

This work was funded by China Postdoctoral Science Foundation (No. 2017M613179) and The National Natural Science Foundation of China (No.81691877).

Author information

Authors and Affiliations

  1. Department of Joint Surgery, Xi’an Hong Hui Hospital, Xi’an Jiaotong University Health Science Center, Xi’an, ShaanXi Province, China

    Chao Lu, Ke Xu, Hao Guo, Kan Peng, Zhi Yang, Yang Quan Hao & Peng Xu

Authors
  1. Chao Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ke Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hao Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kan Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhi Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yang Quan Hao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Peng Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peng Xu.

Ethics declarations

Disclosures

None.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lu, C., Xu, K., Guo, H. et al. The relationship of PADI4_94 polymorphisms with the morbidity of rheumatoid arthritis in Caucasian and Asian populations: a meta-analysis and system review. Clin Rheumatol 37, 289–296 (2018). https://doi.org/10.1007/s10067-017-3964-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-017-3964-3

Keywords

Search

Navigation