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The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population

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Abstract

The Peptidyl arginine deiminase, type IV (PADI4) gene has been suggested to have an association with rheumatoid arthritis (RA) in several populations. But its role in Chinese RA is not clarified. We investigated five single-nucleotide polymorphisms (SNPs) of PADI4 as PADI4-89 (rs11203366), PADI4-90 (rs11203367), PADI4-92 (rs874881) PADI4-94 (rs2240340), and PADI4-104 (rs1748033) in Chinese Han population. A total of 378 unrelated RA patients and 204 healthy controls were genotyped for the five SNPs. Individual allele, genotype and haplotype frequencies were compared between patients and controls. No significant differences in the frequency of PADI4 alleles, genotypes and haplotypes were observed between the patients and controls except PADI4-92. These data indicated that PADI4 polymorphisms were unlikely to play an important role in the susceptibility to RA in Chinese Han population.

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Acknowledgments

We are very grateful to Professor Baohua Qian of Changhai Hospital for Providing Health Controls.

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Authors and Affiliations

  1. Department of Medical Genetics, Second Military Medical University, No. 800 Xiangyin Road, 200433, Shanghai, China

    Ruiwen Chen, Yubao Wei, Meng Fang, Ke Lv, Ning Cheng & Shuhan Sun

  2. Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China

    Qing Cai

  3. Bio-X Life Science Research Center, Shanghai Jiao Tong University, PO Box 501, 200433, Shanghai, China

    Shiwei Duan

  4. State Key Lab of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433, Shanghai, China

    Daming Ren

  5. Guanghua Hospital, 200433, Shanghai, China

    Jie Shen & Dongyi He

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  1. Ruiwen Chen
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  2. Yubao Wei
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  3. Qing Cai
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  4. Shiwei Duan
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  9. Ke Lv
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  10. Ning Cheng
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  11. Shuhan Sun
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Corresponding author

Correspondence to Shuhan Sun.

Additional information

Ruiwen Chen, Yubao Wei and Qing Cai are co-first authors of this work.

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Chen, R., Wei, Y., Cai, Q. et al. The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population. Rheumatol Int 31, 1631–1634 (2011). https://doi.org/10.1007/s00296-010-1519-x

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  • DOI: https://doi.org/10.1007/s00296-010-1519-x

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