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Treatment of intractable skin ulcers caused by vascular insufficiency with allogeneic cultured dermal substitute: a report of eight cases

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Abstract

Chronic leg ulcers have various causes and can be difficult to treat, although topical treatments, including basic fibroblast growth factor and PGE1, have been used. We applied an allogeneic cultured dermal substitute (CDS) to eight patients with intractable ulcers. The patients had various underlying diseases, including diabetes mellitus, systemic lupus erythematosus, antiphospholipid syndrome, necrobiosis lipoidica, stasis dermatitis, livedo vasculopathy, and rheumatoid arthritis. The CDS was prepared by seeding cultured human fibroblasts on a spongy matrix consisting of hyaluronic acid and atelocollagen. Good clinical results were achieved, as demonstrated by reepithelization, healthy granulation tissue formation, and a subsequent decrease in wound size. Daily dressing changes became unnecessary when the allogeneic CDS was used. Based on these results, we suggest that CDS may be useful for the treatment of intractable skin ulcers.

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Acknowledgments

The present study was supported by the Regenerating Medical Millennium Project of the Ministry of Health, Labor and Welfare of Japan.

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Authors and Affiliations

  1. Department of Dermatology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan

    Tomonori Taniguchi, Yasuyuki Amoh, Kenichi Tanabe & Kensei Katsuoka

  2. Research and Development Center for Artificial Skin, Kitasato University School of Allied Health Sciences, Sagamihara, Japan

    Yoshimitsu Kuroyanagi

Authors
  1. Tomonori Taniguchi
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  2. Yasuyuki Amoh
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  3. Kenichi Tanabe
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  4. Kensei Katsuoka
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  5. Yoshimitsu Kuroyanagi
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Correspondence to Tomonori Taniguchi.

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Taniguchi, T., Amoh, Y., Tanabe, K. et al. Treatment of intractable skin ulcers caused by vascular insufficiency with allogeneic cultured dermal substitute: a report of eight cases. J Artif Organs 15, 77–82 (2012). https://doi.org/10.1007/s10047-011-0601-9

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  • DOI: https://doi.org/10.1007/s10047-011-0601-9

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