Abstract
The authors have developed a two-layered spongy matrix composed of hyaluronic acid (HA) and atelo-collagen (Col) as a cultured dermal substitute (CDS). This spongy matrix was applied to a full-thickness skin defect on the dorsum of Sprague-Dawley rats, and the wound conditions were observed over a period of 2 weeks. A piece of two-layered spongy matrix was applied to the wound, over which a commercially available polyurethane film dressing was applied. Both the macroscopic and the histological evaluations indicate that the two-layered spongy matrix is able to prepare a highly vascularized granulation tissue at an early stage. These findings suggest that this type of spongy matrix would be useful as a CDS.
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Received: October 4, 2002 / Accepted: January 23, 2003
Correspondence to:Y. Kuroyanagi
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Kubo, K., Kuroyanagi, Y. Spongy matrix of hyaluronic acid and collagen as a cultured dermal substitute: evaluation in an animal test. J Artif Organs 6, 0064–0070 (2003). https://doi.org/10.1007/s100470300010
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DOI: https://doi.org/10.1007/s100470300010