Abstract
Mesenchymal stem cells can differentiate into various tissue types including bone, cartilage, fat, and muscle. Transforming growth factor-Β (TGFΒ) family members, including TGFΒs and bone morphogenetic proteins (BMPs), play important roles in directing fate decisions for mesenchymal stem cells. TGFΒ can provide competence for early stages of chondroblastic and osteoblastic differentiation, but it inhibits myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. TGFΒ family members signal via specific serine/threonine kinase receptors and their nuclear effectors, termed Smad proteins. In this review we discuss recent advances in our understanding of the molecular mechanisms by which TGFΒ family members control mesenchymal stem cell differentiation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Presented at the 17th Annual Research Meeting of the Japanese Orthopaedic Association, Aomori, Japan, October 2002
About this article
Cite this article
Roelen, B., Dijke, P. Controlling mesenchymal stem cell differentiation by TGFΒ family members. J Orthop Sci 8, 740–748 (2003). https://doi.org/10.1007/s00776-003-0702-2
Received:
Issue Date:
DOI: https://doi.org/10.1007/s00776-003-0702-2