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The role of the CCQM OAWG in providing SI traceable calibrators for organic chemical measurements

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Abstract

Metrological traceability for organic chemical measurements is a documented unbroken chain of calibrations with stated uncertainties that ideally link the measurement result for a sample to a primary calibrator in appropriate SI units (e.g., mass fraction). A comprehensive chemical purity determination of the organic calibrator is required to ensure a true assessment of this result. We explore the evolution of chemical purity capabilities across metrology institute members of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology’s Organic Analysis Working Group (OAWG). The OAWG work program has promoted the development of robust measurement capabilities, using indirect “mass balance” determinations via rigorous assessment of impurities and direct determination using quantitative nuclear magnetic resonance spectroscopy methods. A combination of mass balance and qNMR has been shown to provide a best practice approach. Awareness of the importance of the traceability of organic calibrators continues to grow across stakeholder groups, particularly in key areas such as clinical chemistry where activities related to the Joint Committee for Traceability in Laboratory Medicine have raised the profile of traceable calibrators.

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Adapted from the OAWG strategy document [4]

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Acknowledgements

The authors wish to recognize Steven Westwood of the BIPM for his many years of leadership with the CCQM-K55 series, and for all our colleagues that have both organized and participated in the numerous pilot studies and key comparisons related to chemical purity and qNMR.

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Authors and Affiliations

  1. National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD, 20899-8392, USA

    Katrice A. Lippa, David L. Duewer & Michael A. Nelson

  2. National Measurement Institute, Australia, 105 Delhi Road, North Ryde, NSW, 2113, Australia

    Stephen R. Davies & Lindsey G. Mackay

Authors
  1. Katrice A. Lippa
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  2. David L. Duewer
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  3. Michael A. Nelson
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  4. Stephen R. Davies
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  5. Lindsey G. Mackay
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Correspondence to Lindsey G. Mackay.

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Lippa, K.A., Duewer, D.L., Nelson, M.A. et al. The role of the CCQM OAWG in providing SI traceable calibrators for organic chemical measurements. Accred Qual Assur 24, 407–415 (2019). https://doi.org/10.1007/s00769-019-01407-6

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