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Mass balance method for purity assay of phthalic acid esters: development of primary reference materials as traceability sources in the Japan Calibration Service System

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An Erratum to this article was published on 19 April 2011

Abstract

Purity assay of high-purity materials (HPMs) of phthalic acid esters (PAEs) was carried out by means of a mass balance method. In this method, chromatographic methods such as gas chromatography-flame ionization detector (GC-FID) and/or high-performance liquid chromatography (HPLC) in combination with other methods such as Karl-Fischer (KF) titration and vacuum evaporation (VE) were applied. The sum of the impurities estimated by these methods allowed the estimation of the purity of the main component by difference. Seven PAEs with varying side chain structures and levels of impurities were analysed on a systematic way in which impurities were classified into several groups in terms of their abundance, availability of qualitative information and availability of authentic compounds, etc. The absolute quantity of each impurity was determined by GC-FID and/or HPLC based on the calibration made by the authentic compounds of impurities whenever available. The purities in mass fraction of these PAEs were certified at the National Metrology Institute of Japan (NMIJ), and the PAEs were registered as primary reference materials playing an essential role in linking the metrological traceability of the Japan Calibration Service System (JCSS) to the International System of Units (SI).

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Acknowledgments

We acknowledge the collaborators for the preparations of the candidate reference materials, and the NMIJ analysts who helped in the development of the CRMs described in this paper.

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Authors and Affiliations

  1. National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 3, Umezono, Tsukuba, 305-8563, Japan

    Keiichiro Ishikawa, Nobuyasu Hanari, Yoshitaka Shimizu, Toshihide Ihara, Akira Nomura, Masahiko Numata, Takashi Yarita, Kenji Kato & Koichi Chiba

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  1. Keiichiro Ishikawa
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  2. Nobuyasu Hanari
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  3. Yoshitaka Shimizu
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  4. Toshihide Ihara
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  5. Akira Nomura
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  6. Masahiko Numata
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  7. Takashi Yarita
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  8. Kenji Kato
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  9. Koichi Chiba
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Corresponding author

Correspondence to Keiichiro Ishikawa.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00769-011-0776-z

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Ishikawa, K., Hanari, N., Shimizu, Y. et al. Mass balance method for purity assay of phthalic acid esters: development of primary reference materials as traceability sources in the Japan Calibration Service System. Accred Qual Assur 16, 311–322 (2011). https://doi.org/10.1007/s00769-011-0767-0

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  • DOI: https://doi.org/10.1007/s00769-011-0767-0

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