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A concise stereoselective total synthesis of (−)-cephalosporolide D

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Abstract

A concise stereoselective total synthesis of eight-membered lactone (−)-cephalosporolide D has been derived from inexpensive and commercially available starting material (S)-propylene epoxide. This concise synthesis utilizes Grignard reaction, Noyori asymmetric reduction, and Yamaguchi macrolactonization as key steps.

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, 522 510, Guntur, Andhra Pradesh, India

    Gurrala Alluraiah, Reddymasu Sreenivasulu & Rudraraju Ramesh Raju

  2. Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, 500 085, India

    Palle Sadanandam

  3. Department of Chemistry, Sri Krishnadevaraya University, 515 003, Anantapur, Andhra Pradesh, India

    Kowthalam Anitha

Authors
  1. Gurrala Alluraiah
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  2. Reddymasu Sreenivasulu
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  3. Palle Sadanandam
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  4. Kowthalam Anitha
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  5. Rudraraju Ramesh Raju
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Corresponding author

Correspondence to Rudraraju Ramesh Raju.

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Alluraiah, G., Sreenivasulu, R., Sadanandam, P. et al. A concise stereoselective total synthesis of (−)-cephalosporolide D. Monatsh Chem 147, 451–455 (2016). https://doi.org/10.1007/s00706-015-1526-4

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  • DOI: https://doi.org/10.1007/s00706-015-1526-4

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