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Aldimines of 5-aminouracil as reagents in 1,3-dipolar cycloaddition reaction

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Abstract

The condensation of 5-aminouracil with aromatic aldehydes gave the appropriate C-arylimines, which were used in [2+3] cycloaddition with nitrile oxides derived from 4-substituted benzaldoximes. As a result of the dipolar cycloaddition reaction several hitherto unknown 5-(3,5-diphenyl-1,2,4-oxadiazol-4(5H)-yl)pyrimidine-2,4(1H,3H)-diones have been obtained in satisfactory yields.

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Acknowledgments

The authors thank the National Science Centre in Poland (grant no. N N204347840) for financial support.

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Authors and Affiliations

  1. Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100, Gliwice, Poland

    Dominika Jakubiec & Krzysztof Z. Walczak

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  1. Dominika Jakubiec
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  2. Krzysztof Z. Walczak
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Correspondence to Krzysztof Z. Walczak.

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Jakubiec, D., Walczak, K.Z. Aldimines of 5-aminouracil as reagents in 1,3-dipolar cycloaddition reaction. Monatsh Chem 142, 1155–1161 (2011). https://doi.org/10.1007/s00706-011-0616-1

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  • DOI: https://doi.org/10.1007/s00706-011-0616-1

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