Summary.
Twenty MV strains obtained from a survey of field strains currently circulating throughout Spain were analyzed for their virulence and horizontal spreading among rabbits by contact transmission. A virus strain with suitable characteristics to be used as a potential vaccine against myxomatosis in wild rabbit populations was selected. Following inoculation, the selected MV strain elicited high levels of MV specificantibodies and induced protection of rabbits against a virulent MV challenge. Furthermore, the attenuated MV was transmitted to 9 out of 16 uninoculated rabbits by contact, inducing protection against myxomatosis.
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Received June 10, 1999/Accepted October 7, 1999
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Bárcena, J., Pagès-Manté, A., March, R. et al. Isolation of an attenuated myxoma virus field strain that can confer protection against myxomatosis on contacts of vaccinates. Arch. Virol. 145, 759–771 (2000). https://doi.org/10.1007/s007050050669
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DOI: https://doi.org/10.1007/s007050050669