Summary
Oligodendroglioma cells are detectable in the cerebro-spinal fluid in up to 14% of patients [10] and cerebellar and/or spinal cord involvement is a well known phenomenon [3]. Distant spread of oligodendroglioma is exceptional, probably due to the presence of the blood-brain barrier, the absence of lymphatic vessels and the short survival of patients.
A review of the worldwide literature yielded 32 previously reported examples since 1951 to the present (Tab1e 1). This review was performed using NCBI-PubMed and “oligodendroglioma, oligodendrogliomas, metastatic, metastasis, metastases, extraneural”, in different combinations, as key words and reviewing the bibliography of the consequent selected articles.
New therapeutic approaches are prolonging the overall survival of patients with primitive brain tumours and in particular of those with high grade oligodendroglioma which is a chemo-sensitive disease. A longer overall survival could increase the risk of extracranial dissemination of gliomas that in the future might become a less rare clinical complication.
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References
F Al Ali AJ Hendon MK Liepman JL Wisniewsky MJ Krinock K Beckman (2005) ArticleTitleOligodendroglioma metastatic to bone marrow Am J Neuroradiol 26 2410–2414 Occurrence Handle16219856
M Anand R Kumar P Jain R Gupta N Ghosal A Sharma A Agarwal MC Sharma (2003) ArticleTitleMetastatic anaplastic oligodendroglioma simulating acute leukaemia Acta Cytol 47 467–469 Occurrence Handle12789933
DJK Beck D Russel (1942) ArticleTitleOligodendrogliomatosis of the cerebro-spinal pathway Brain 65 352–372 Occurrence Handle10.1093/brain/65.4.352
WL Brander DR Turner (1975) ArticleTitleExtracranial metastases from a glioma in the absence of surgical intervention J Neurol Neurosurg Psychiatry 38 1133–1135 Occurrence Handle1206423 Occurrence Handle1:STN:280:DyaE28%2Fps1KrsQ%3D%3D
P Cappalaere A Clay L Adenis A Demaille E Laine (1972) ArticleTitleLes metastases des tumours cerebrales primitives en dehors du nevraxe: a propos de trios observations Bull Cancer (Paris) 59 235–254
A Choon JE Roepke (2004) ArticleTitleImportance of immunohistochemichal staining in metastatic anaplastic oligodendroglioma Arch Pathol Lab Med 128 489–490 Occurrence Handle15043478
TP Dawson (1997) ArticleTitleCase report. Pancytopenia from a disseminated anaplastic oligodendroglioma Neuropathol App Neurobiol 23 516–520 Occurrence Handle10.1111/j.1365-2990.1997.tb01330.x Occurrence Handle1:STN:280:DyaK1c7it1Smsw%3D%3D
OE Eade H Urich (1971) ArticleTitleMetastasising gliomas in young subjects J Pathol 103 245–256 Occurrence Handle5563877 Occurrence Handle10.1002/path.1711030407 Occurrence Handle1:STN:280:DyaE3M3msFCrsA%3D%3D
SA Ely DM Knowles (2002) ArticleTitleExpression of CD56/Neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmocytoid differentiation Am J Pathol 160 1293–1299 Occurrence Handle11943714
Engherland HH (2002) Current diagnosis and treatment of oligodendroglioma. Neurosurg Focus 12, article 2
P Garin-Chesa EJ Fellinger AG Huvos R Beresford MR Melamed TJ Triche WJ Rettig (1991) ArticleTitleImmunohistochemical analysis of neural cell adhesion molecules Am J Pathol 139 275–286 Occurrence Handle1867319 Occurrence Handle1:STN:280:DyaK3MzivVaqug%3D%3D
GE Gerrard MG Bond AS Jack (1995) ArticleTitleBone marrow infiltration by a parietal lobe grade III oligodendroglioma Clin Oncol 7 321–322 Occurrence Handle10.1016/S0936-6555(05)80543-6 Occurrence Handle1:STN:280:DyaK287islersQ%3D%3D
MT Giordana S Gasverde I Balteri (2002) ArticleTitleBone metastasis of oligodendrogliomas: clinical and molecular genetic study Neuro-Oncology 4 38e Occurrence Handle10.1215/15228517-4-2-115
TGI James W Pagel (1951) ArticleTitleOligodenroglioma with extracranial metastases Br J Surg 39 56–65 Occurrence Handle14858828 Occurrence Handle10.1002/bjs.18003915312 Occurrence Handle1:STN:280:DyaG3M%2FovVekug%3D%3D
K Jellinger M Minauf M Salzer-Kuntschik (1969) ArticleTitleOligodendroglioma with extraneural metastases J Neurol Neurosurg Psychiatry 32 249–253 Occurrence Handle5795118 Occurrence Handle1:STN:280:DyaF1M3js12huw%3D%3D
JW Kernohan (1971) Oligodendrogliomas J Minckler (Eds) Pathology of the nervous system NumberInSeries2 McGraw-Hill Co New York 1993–2007
RV Kummer B Volk W Dorndorf (1969) ArticleTitleExtraneural metastasierendes oligodendrogliom Arch Psychiatr Nervenkr 223 287–293 Occurrence Handle10.1007/BF00346506
DR Macdonald RA O’Brien JJ Gilbert JG Cairncross (1989) ArticleTitleMetastatic anaplastic oligodendroglioma Neurology 39 1593–1596 Occurrence Handle2685656 Occurrence Handle1:STN:280:DyaK3c%2FmslSqsA%3D%3D
V Monzani A Rovellini B Masini E Cappricci G Miserocchi (1996) ArticleTitleMetastatic oligodendroglioma. Case report J Neurol Sci 40 239–241 Occurrence Handle1:STN:280:DyaK2szgvVajtQ%3D%3D
T Morrison JM Bilbao G Yang JR Perry (2004) ArticleTitleBony metastases of anaplastic oligodendroglioma respond to temozolomide Can J Neurol Sci 31 102–108 Occurrence Handle15038479
O Nakamura T Watanabe K Nomura T Nakajima (1985) ArticleTitleDiffuse bone marrow metastasis of an anaplastic oligodendroglioma No Shinkei Geka 13 903–909 Occurrence Handle4058667 Occurrence Handle1:STN:280:DyaL28%2FktVKrsQ%3D%3D
HFV Newman GCV Howard PM Reid (1985) ArticleTitleMetastatic oligodendroglioma presenting as a leukoerythroblastic anaemia Eur J Surg Onc 11 287–288 Occurrence Handle1:STN:280:DyaL2M3osFKmsg%3D%3D
NG Ordonez AA Ayala ME Leavens (1981) ArticleTitleExtracranial metastases of oligodenroglioma: report of a case and review of the literature Neurosurgery 8 391–395 Occurrence Handle7242888 Occurrence Handle1:STN:280:DyaL3M3itFeruw%3D%3D Occurrence Handle10.1227/00006123-198103000-00012
H Schuster K Jellinger A Gund H Regele (1976) ArticleTitleExtracranial metastases of anaplastic cerebral gliomas Acta Neurochir (Wien) 35 247–259 Occurrence Handle10.1007/BF01406121 Occurrence Handle1:STN:280:DyaE2s%2Fmt1Kgtg%3D%3D
A Sharma A Agarwal MC Sharma M Anand S Agarwal V Raina (2003) ArticleTitleBone marrow metastasis in anaplastic oligodendroglioma Int J Clin Pract 57 351–352 Occurrence Handle12800473 Occurrence Handle1:STN:280:DC%2BD3s3nsVCntg%3D%3D
DR Smith JM Hardman KM Earle (1969) ArticleTitleMetastasising neuroectodermal tumours of the central nervous system J Neurosurg 31 50–58 Occurrence Handle4307543 Occurrence Handle1:STN:280:DyaF1M3js12nsg%3D%3D
J Spataro O Sacks (1968) ArticleTitleOligodendroglioma with remote metastases. Case report J Neurosurg 28 373–379 Occurrence Handle5643931 Occurrence Handle1:STN:280:DyaF1c7pt1Wgug%3D%3D Occurrence Handle10.3171/jns.1968.28.4.0373
T Uzuka A Kakita C Inenaga H Takahashi R Tanaka H Takahashi (2007) ArticleTitleFrontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course Neurol Med Chir (Tokyo) 47 174–177 Occurrence Handle10.2176/nmc.47.174
X Wang H Hisha S Taketani M Inaba Q Li W Cui C Song T Fan Y Cui G Yang H Fan Z Lian E Gershwin S Ikehara (2005) ArticleTitleNeural Cell Adhesion Molecule Contributes to hemopoiesis-supporting capacity of stromal cell lines Stem Cells 23 1389–1399 Occurrence Handle16051987 Occurrence Handle10.1634/stemcells.2004-0343 Occurrence Handle1:CAS:528:DC%2BD2MXhtF2lu7zN
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Correspondence: Fable Zustovich, Oncologia Medica 1, Istituto Oncologico Veneto, I.R.C.C.S, Padova, Italy; Ospedale Busonera, Via Gattamelata 64, 35128 Padova, Italy.
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Zustovich, F., Della Puppa, A., Scienza, R. et al. Metastatic oligodendrogliomas: a review of the literature and case report. Acta Neurochir (Wien) 150, 699–703 (2008). https://doi.org/10.1007/s00701-008-1507-z
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DOI: https://doi.org/10.1007/s00701-008-1507-z