Summary
Seven cases are reported of anaplastic cerebral gliomas with metastases outside the neuraxis, seen among about 1500 gliomas. There were two children with anaplastic ependymomas, one adult with oligodendroglioma, and four young to middle-aged adults with astrocytomas grade III and IV. All patients had one or more craniotomies, and four had radiotherapy prior to the appearance of distant tumour deposits. The survival times ranged from 7 to 31 months in cases with gliomas grade II, and from 8 to 18 months with high grade astrocytomas. All seven tumours showed invasion of the meninges, ventricular walls, or both, and in four cases they transgressed the dura and surrounding bone or soft tissues. In six autopsy cases there was widespread dissemination of gliomas through the CSF pathways. Distant metastases involved regional or distant lymph nodes in six patients, the lungs in two, and the vertebrae, pleura, liver, or mediastinum in one patient each. The possible pathways for distant spread of intracranial gliomas and the factors which are considered responsible are briefly discussed.
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References
Anzil, A. P., Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. Case report. J. Neurosurg.33 (1970), 88–94.
Bogdanovich, N. K., K voprosu o metastaziruyushchikh opukholyakh golovnagu mozgu. Arkh. Path. (Moskau)20 (1958), 83–86.
Brander, W. L., Turner, D. R., Extracranial metastases from a glioma in the absence of surgical intervention. J. Neurol. Psychiat. Neurosurg.38 (1975), 1133–1135.
Brust, J. C. M., Moiel, R. H., Rosenberg, R. N., Glial tumor metastases through a ventriculo-pleural shunt. Arch. Neurol. (Chic.)18 (1968), 649–653.
Cappelaere, P., Cla, A., Adenis, L., Demaille, A., Laine, E., Les métastases des tumeurs cérébrales primitives en dehors du névraxe. Bull. Cancer59 (1972), 235–254.
Dolman, C. L., Lymph node metastasis as first manifestation of glioblastoma. J. Neurosurg.41 (1974), 607–609.
Eade, O. E., Urich, H., Metastasizing gliomas in young subjects. J. Path. (Edinbg.)103 (1971), 245–256.
El-Gindi, S., Salama, M., El-Henawy, M., Farag, S., Metastases of glioblastoma multiforme to cervical lymph nodes. J. Neurosurg.38 (1973), 631–634.
Fisher, E. R., Fisher, B., Immunologic factors in experimental metastases formation. Int. J. Radiol. Oncol.1 (1975), 87–92.
Földi, M., Physiologie und Pathophysiologie des Lymphgefäßsystems. In: Alt-mann, H.-W.,et al. (eds.): Handbuch der allgemeinen Pathologie, Vol. III, Part 6, pp. 239–310. Berlin-Heidelberg-New York: Springer. (1972).
Gropp, A., Über ein metastasierendes „Gliom“. Z. Krebsforsch.60 (1955), 590–596.
Højgaard, K., Johansen, A., A case of ependymoma with remote metastasis. Acta path, microbiol. scand. Suppl.212 (1970), 198–200.
Jellinger, K., Minauf, M., Salzer-Kuntschik, M., Oligodendroglioma with extraneural metastases. J. Neurol. Psychiat. Neurosurg.32 (1969), 249–253.
Komatsu, K., Inaba, Y., Hiratsuka, H., Extensive extra-cranial metastases of glioblastoma multiforme. Brain Nerve (Tokyo)14 (1972), 339–351.
Koos, W. T., Miller, M., Intracranial tumors of infants and children. Stuttgart: G. Thieme. 1971.
Kretschmer, H., Die extrakranielle Metastasierung intrakranieller Geschwülste. Zbl. Neurochir.35 (1974), 81–112.
Kung, P. C., Lee, J. C., Bakay, L., Vascular invasion by glioma cells. An electron microscopic study. J. Neurosurg.31 (1969), 339–345.
Minauf, M., Jellinger, K., Meningeales Wachstum von Oligodendrogliomen. Acta Neurochir. (Wien)19 (1968), 269–280.
Morley, T. P., The recovery of tumour cells from venous blood draining cerebral gliomas. A preliminary report. Can. J. Surg.2 (1959), 363–365.
Mracek, Z., Janda, J., Glioblastoma multiforme s extrakranialnimi metastazami. Cs. Neurol. Neurochir.38 (1975), 19–24.
Pe, K. M., Oligodendroglioma with extracranial metastases. Zhong Waike Z.11 (1962), 635–637.
Ridley, A., Immunological reactions to gliomas. In: D. Williams, ed., Modern trends in Neurology, Vol. 6, p. 249–266. London: Butterworths. (1975).
Rubinstein, L. J., Extracranial metastases from a malignant astrocytoma in the absence of previous craniotomy. J. Neurosurg.26 (1967), 542–547.
—, Tumors of the central nervous system. Atlas of Tumor Pathology, 3rd edit., Fasc. 6. Washington, D.C.: Armed Forces Institute of Pathology. (1972).
Smith, D. R., Hardman, J. M., Earle, K. M., Metastasizing neuroectodermal tumors of the central nervous system. J. Neurosurg.31 (1969), 50–58.
Wakamatsu, T., Extracranial metastasis of intracranial tumor. Acta path. jap.22 (1974), 155–169.
—, Matsuo, T., Kawano, S., Teratomo, S., Watsumara, H., Glioblastoma with extracranial metastasis through ventriculopleural shunt. J. Neurosurg.34 (1971), 697–701.
Weiss, L., A metastasizing ependymoma of the cauda equina. Cancer8 (1955), 161–171.
Willis, R. A., The spread of tumors in the human body. 3rd ed. London: Butterworths. (1973).
Wolf, A., Cowen, D., Stewart, W. B., Glioblastoma with extracranial metastasis by way of a ventriculopleural anastomosis. Trans. Amer. Neurol. Ass.79 (1954), 140–142.
Zeitelhofer, J., Kraus, H., Über die extrakranielle Metastasierung der Gliome. Zbl. Neurochir.12 (1952), 347–358.
Zimmerman, H. M., An explanation of certain glioma problems. J. Mt. Sinai Hosp.24 (1957), 1357–1362.
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Schuster, H., Jellinger, K., Gund, A. et al. Extracranial metastases of anaplastic cerebral gliomas. Acta neurochir 35, 247–259 (1976). https://doi.org/10.1007/BF01406121
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DOI: https://doi.org/10.1007/BF01406121