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Synergic effect of Pt-Co nanoparticles and a dopamine derivative in a nanostructured electrochemical sensor for simultaneous determination of N-acetylcysteine, paracetamol and folic acid

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Abstract

A carbon paste electrode (CPE) was modified with Pt-Co nanoparticles and 2-(3,4-dihydroxyphenethyl)isoindoline-1,3-dione (3,4-DHPID) and then used for determination of N-acetylcysteine (N-AC) in the presence of paracetamol (PC) and folic acid (FA). The Pt-Co nanoparticles were synthesized by the polyol method and characterized by X-ray diffraction, energy dispersive X-ray analysis and transmission electron microscopy. The modified CPE displays good electrocatalytic activity towards the electrooxidation of N-AC in solution of pH 7.0. It was applied to the determination of N-AC in the presence of PC and FA (with well separated signals peaking at 0.2, 0.55 and 0.86 V vs. Ag/AgCl) by using square wave voltammetry. The peak currents are linearly dependent on the concentrations of N-AC, PC and FA in the respective ranges from 0.07 to 500, 1.0 to 850, and 2.0 to 550 μmol·L−1, with detection limits of 0.009, 0.6 and 0.8 μmol·L−1. The modified CPE was applied to the determination of N-AC, PC and FA in (spiked) pharmaceutical and biological samples.

Pt-Co nanoparticles and 2-(3,4-dihydroxyphenethyl)isoindoline-1,3-dione were used for modification of a carbon paste electrode which then was used for sensitive determination of N-actylcysteine in the presence of paracetamol and folic acid.

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Acknowledgments

The authors gratefully acknowledge Iran National Science Foundation (INSF) for support of this work under project No. 92036148 and Graduate University of Advanced Technology, Kerman, Iran for their cooperation.

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Authors and Affiliations

  1. Department of Chemistry, Graduate University of Advanced Technology, Kerman, 76311-33131, Iran

    Hassan Karimi-Maleh

  2. Polymer Research Laboratory, University of Bonab, Bonab, 55517-61167, Iran

    Mehdi Hatami

  3. Department of Physics, Qaemshahr Branch, Islamic Azad University, Qaemshahr, 47651-61964, Iran

    Reza Moradi

  4. Department of Chemistry, Sari Branch, Islamic Azad University, Sari, 48161-19318, Iran

    Mohammad A. Khalilzadeh

  5. Department of Physics, Science and Research Branch, Islamic Azad University, Mazandaran, 48161-19318, Iran

    Sedighe Amiri

  6. Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695-8005, USA

    Hasan Sadeghifar

Authors
  1. Hassan Karimi-Maleh
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  2. Mehdi Hatami
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  3. Reza Moradi
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  4. Mohammad A. Khalilzadeh
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  5. Sedighe Amiri
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  6. Hasan Sadeghifar
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Correspondence to Hassan Karimi-Maleh.

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Karimi-Maleh, H., Hatami, M., Moradi, R. et al. Synergic effect of Pt-Co nanoparticles and a dopamine derivative in a nanostructured electrochemical sensor for simultaneous determination of N-acetylcysteine, paracetamol and folic acid. Microchim Acta 183, 2957–2964 (2016). https://doi.org/10.1007/s00604-016-1946-9

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  • DOI: https://doi.org/10.1007/s00604-016-1946-9

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