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A nanostructure-based electrochemical sensor for square wave voltammetric determination of N-acetylcysteine in pharmaceutical and biological samples

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Abstract

In this study, a carbon paste electrode (CPE) was chemically modified with Pt/carbon nanotubes (CNTs) nanocomposite and 8,9-dihydroxy-7-methyl-12H-benzothiazolo [2,3-b] quinazolin-12-one (DMBQ). The synthesized nanocomposite was characterized with different methods such as transmission electron microscopy (TEM) and X-ray diffraction (XRD). The modified electrode was used as an electrochemical sensor for the determination of trace amounts of N-acetylcysteine (N-AC). The propose sensor showed very efficient electrocatalytic activity for the anodic oxidation of N-AC, owing to a substantial decrease in anodic overpotentials. The peak current of square wave voltammograms (SWV) of N-AC increased linearly with its concentration in the range of 0.1–600 μM. The detection limit was 0.07 μM at a signal-to-noise ratio of 3, using square wave voltammetry. The modified electrode has been successfully applied for the assay of N-AC in pharmaceutical and biological samples.

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Acknowledgments

We are grateful to the Sari Branch, Islamic Azad University, Sari, Iran and Kerman Graduate University of Advanced Technology and the Iranian Nanotechnology Initiative Council for their support.

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Authors and Affiliations

  1. Department of Chemistry, Sari Branch, Islamic Azad University, Sari, Iran

    Vahid Arabali

  2. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran

    Hassan Karimi-Maleh

  3. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi

  4. Department of Physics, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

    Reza Moradi

  5. Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    Mahmoud Ebrahimi

  6. Department of Chemistry, Faculty of Sciences, University of Zabol, P.O. Box 98615-538, Zabol, IR, Iran

    Hamid Ahmar

Authors
  1. Vahid Arabali
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  2. Hassan Karimi-Maleh
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  3. Hadi Beitollahi
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  4. Reza Moradi
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  5. Mahmoud Ebrahimi
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  6. Hamid Ahmar
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Correspondence to Vahid Arabali or Hassan Karimi-Maleh.

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Arabali, V., Karimi-Maleh, H., Beitollahi, H. et al. A nanostructure-based electrochemical sensor for square wave voltammetric determination of N-acetylcysteine in pharmaceutical and biological samples. Ionics 21, 1153–1161 (2015). https://doi.org/10.1007/s11581-014-1271-4

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  • DOI: https://doi.org/10.1007/s11581-014-1271-4

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