Abstract
The efficacy of dihydropyridine derivatives in inhibiting lipid peroxidation was studied using modified Buege and Aust’s method. The method first involves keeping a decapitated rat head at 37°C for 30 min in order to induce global ischemia. Then, the cortex is removed and homogenized, and the homogenate is subsequently exposed to air for 30 min for reoxygenation. Finally, the amount of thiobarbituric acid-reactive substances (TBAR) is measured. With this method, nisoldipine, nimodipine, nitrendipine, nifedipine and nicardipine were all shown to have an antioxidant activity that correlated with their lipophilicity, which was determined by their octanol/water partition coefficients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hoffmeister F, Benz U, Heise A, et al: Behavioral effects of nimodipine in animals. Arzneim Forsch 32:347–360, 1982
Kazda S, Garthoff B, Krause HP, et al: Cerebrovasucular effects of the calcium antagonistic dihydropyridine derivative, nimodipine, in animal experiments. Arzneim Forsch 32:331–338, 1982
Cohen RJ, Allen GS: Cerebral arterial spasm: the role of calcium in vitro and in vivo analysis of treatment with nifedipine and nimodipine, Proceeding of the 2nd International Workshop on Vasospasm. Edited by Wilkins RH. Baltimore, Williams & Wilkins, 1980, pp. 527–532
Germano IM, Bsrtokowski HM, Cassel ME, et al: The therapeutic value of nimodipine in experimental cerebral ischemia: Neurological outcome and histopathologic findings. J Neurosurg 67:81–87, 1987
Meyer FB, Anderson RE, Yaksh TL, et al: Effect of nimodipine on intracellular brain pH, cortical blood flow and EEG in experimental focal cerebral ischemia. J Neurosurg 64:617–624, 1986
Steen PA, Gisvold SE, Milde JH, et al: Nimodipine improves outcome when given after complete cerebral ischemia in primates. Anesthesiology 62:406–411, 1985
Steen PA, Newberg LA, Milde JH, et al: Cerebral blood flow and neurological outcome when nimodipine is given after complete cerebral ischemia in the dog. J Cereb Blood Flow Metab 4:82–87, 1984
Meyer FB, Anderson RE, Sundt TM, et al: Suppression of pentylenetetrazole seizures by oral administration of a dihydropyridine Ca2+ antagonist. Epilepsia 28:409–414, 1987
Meyer FB, Tally PW, Anderson RE, et al: Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. Brain Res 384:180–183, 1986
Lefer AM, Carrow BA: Salutary action of nimodipine in traumatic shock. Life Sci 29:1347–1353, 1981
Hock CE, Su JY, Lefer AM: Salutary effects of nitrendipine, a new calcium entry blocker, in hemorrhagic shock. Eur J Pharmacol 97:37–46, 1984
Okamatsu S, Peck RC, Lefer AM: Effects of calcium channel blockers on arachidonate-induced sudden death in rabbits. Proc Soc Exp Biol Med 166:551–555, 1981
Ondrias K, Misik V, Gergel D, et al: Lipid peroxidation of phosphatidylcholine liposomes depressed by the calcium channel blockers nifedipine and verapamil and by the antiarrhythmic-antihypoxic durg stobine. Biochem Biophys Acta 1003:238–245, 1989
Sakamoto A, Ohnishi ST, Ohnishi T, et al: Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain. Brain Research 554:186–192, 1991
Hall ED, Pazara KE, Braughler JM: 21-aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke 67:81–87, 1987
Liu TH, Beckman JS, Freeman BA, et al: Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol 256:H589–593, 1989
Sakamoto, A, Ohnishi ST, Ohnishi T, et al: Protective effect of a new antioxidant on the rat brain exposed to ischemia-reperfusion injury: Inhibition of free radical formation and lipid peroxidation. Free Radic Biol Med 11:385–391, 1991
Ohnishi ST, Sakamoto A, Ohnishi T, et al: Inhibition of lipid peroxidation by prostaglandin oligomeric derivatives. Prostag Leuko Essentl Fatty Acids 45:217–221, 1992
Ohnishi ST, Katsuoka M: Prostaglandin Oligomeric derivatives inhibitin vitro formation of dehydrated cells from sickle red cells. Prostag Leuko Essentl Fatty Acids 37:197–202, 1989
Beuge JA, Aust SD: Microsomal lipid peroxidation, Methods Enzymol Vol 52. Edited by Fleischer S, Packer L. New York, Acad Press, 1978, pp. 302–310
Scriabine A, Schuurman T, Traber J: Pharmacological basis for the use of nimodipine in central nervous system disorders. FASEB J 3:1800–1805, 1989
Author information
Authors and Affiliations
About this article
Cite this article
Sakamoto, A., Ohnishi, S.T. & Ogawa, R. Inhibition of lipid peroxidation by some dihydropyridine derivatives. J Anesth 7, 193–197 (1993). https://doi.org/10.1007/s0054030070193
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s0054030070193